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Role of endothelin receptor type B (EDNRB) in lung adenocarcinoma

BACKGROUND: The five‐year survival rate of lung adenocarcinoma patients (LUAD) is very low,and the methods of predicting survival are a great obstacle for LUAD therapies. Endothelin receptor type B (EDNRB) gene is associated with tumorigenesis. In this study, we aimed to evaluate the predictive valu...

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Autores principales: Wei, Feiran, Ge, You, Li, Wei, Wang, Xuerong, Chen, Baoan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327673/
https://www.ncbi.nlm.nih.gov/pubmed/32394530
http://dx.doi.org/10.1111/1759-7714.13474
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author Wei, Feiran
Ge, You
Li, Wei
Wang, Xuerong
Chen, Baoan
author_facet Wei, Feiran
Ge, You
Li, Wei
Wang, Xuerong
Chen, Baoan
author_sort Wei, Feiran
collection PubMed
description BACKGROUND: The five‐year survival rate of lung adenocarcinoma patients (LUAD) is very low,and the methods of predicting survival are a great obstacle for LUAD therapies. Endothelin receptor type B (EDNRB) gene is associated with tumorigenesis. In this study, we aimed to evaluate the predictive value of EDNRB on LUAD. METHODS: Survival analyses was performed to assess the correlation between EDNRB expression and survival of LUAD patients from the Cancer Genome Atlas (TCGA) and the Chinese Glioma Genome Atlas (CGGA) datasets. Gene set enrichment analysis (GSEA) was conducted to illustrate possible biological functions of EDNRB. Laboratory methods were used to verify the function of EDNRB in LUAD. RESULTS: The TCGA results showed that a low expression of EDNRB was found in LUAD patients which led to poor outcome and worse survival, compared with the high expression in GSEA results which suggested that expression of EDNRB might be associated with regulation of the ERK pathway. Laboratory results suggested that EDNRB could inhibit the proliferation and migration of LUAD H1299 cells. CONCLUSIONS: EDNRB is a potential prognostic marker for LUAD patients and might exert its functions by regulating the ERK pathway in LUAD.
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spelling pubmed-73276732020-07-02 Role of endothelin receptor type B (EDNRB) in lung adenocarcinoma Wei, Feiran Ge, You Li, Wei Wang, Xuerong Chen, Baoan Thorac Cancer Original Articles BACKGROUND: The five‐year survival rate of lung adenocarcinoma patients (LUAD) is very low,and the methods of predicting survival are a great obstacle for LUAD therapies. Endothelin receptor type B (EDNRB) gene is associated with tumorigenesis. In this study, we aimed to evaluate the predictive value of EDNRB on LUAD. METHODS: Survival analyses was performed to assess the correlation between EDNRB expression and survival of LUAD patients from the Cancer Genome Atlas (TCGA) and the Chinese Glioma Genome Atlas (CGGA) datasets. Gene set enrichment analysis (GSEA) was conducted to illustrate possible biological functions of EDNRB. Laboratory methods were used to verify the function of EDNRB in LUAD. RESULTS: The TCGA results showed that a low expression of EDNRB was found in LUAD patients which led to poor outcome and worse survival, compared with the high expression in GSEA results which suggested that expression of EDNRB might be associated with regulation of the ERK pathway. Laboratory results suggested that EDNRB could inhibit the proliferation and migration of LUAD H1299 cells. CONCLUSIONS: EDNRB is a potential prognostic marker for LUAD patients and might exert its functions by regulating the ERK pathway in LUAD. John Wiley & Sons Australia, Ltd 2020-05-12 2020-07 /pmc/articles/PMC7327673/ /pubmed/32394530 http://dx.doi.org/10.1111/1759-7714.13474 Text en © 2020 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Wei, Feiran
Ge, You
Li, Wei
Wang, Xuerong
Chen, Baoan
Role of endothelin receptor type B (EDNRB) in lung adenocarcinoma
title Role of endothelin receptor type B (EDNRB) in lung adenocarcinoma
title_full Role of endothelin receptor type B (EDNRB) in lung adenocarcinoma
title_fullStr Role of endothelin receptor type B (EDNRB) in lung adenocarcinoma
title_full_unstemmed Role of endothelin receptor type B (EDNRB) in lung adenocarcinoma
title_short Role of endothelin receptor type B (EDNRB) in lung adenocarcinoma
title_sort role of endothelin receptor type b (ednrb) in lung adenocarcinoma
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327673/
https://www.ncbi.nlm.nih.gov/pubmed/32394530
http://dx.doi.org/10.1111/1759-7714.13474
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