Lung cancer increases H(2)O(2) concentration in the exhaled breath condensate, extent of mtDNA damage, and mtDNA copy number in buccal mucosa

We have shown that the H(2)O(2) concentration in exhaled breath condensate (EBC) in lung cancer patients increases significantly compared to the EBC of healthy people and revealed the correlation between the H(2)O(2) level in the EBC and amount of mtDNA damage in buccal mucosa cells. The H(2)O(2) hy...

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Autores principales: Kolbasina, Natalya A., Gureev, Artem P., Serzhantova, Olga V., Mikhailov, Andrey A., Moshurov, Ivan P., Starkov, Anatoly A., Popov, Vasily N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327746/
https://www.ncbi.nlm.nih.gov/pubmed/32637695
http://dx.doi.org/10.1016/j.heliyon.2020.e04303
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author Kolbasina, Natalya A.
Gureev, Artem P.
Serzhantova, Olga V.
Mikhailov, Andrey A.
Moshurov, Ivan P.
Starkov, Anatoly A.
Popov, Vasily N.
author_facet Kolbasina, Natalya A.
Gureev, Artem P.
Serzhantova, Olga V.
Mikhailov, Andrey A.
Moshurov, Ivan P.
Starkov, Anatoly A.
Popov, Vasily N.
author_sort Kolbasina, Natalya A.
collection PubMed
description We have shown that the H(2)O(2) concentration in exhaled breath condensate (EBC) in lung cancer patients increases significantly compared to the EBC of healthy people and revealed the correlation between the H(2)O(2) level in the EBC and amount of mtDNA damage in buccal mucosa cells. The H(2)O(2) hyper-production may trigger mitochondrial biogenesis, thereby resulting in an increase in mtDNA copy number. However, we did not observe a significant difference in the studied parameters between smokers and non-smokers. Overall, our data suggest that H(2)O(2) concentration in the EBC, the extent of mtDNA damage, and mtDNA copy number in buccal mucosa could be potential as an early diagnostic marker of lung cancer.
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spelling pubmed-73277462020-07-06 Lung cancer increases H(2)O(2) concentration in the exhaled breath condensate, extent of mtDNA damage, and mtDNA copy number in buccal mucosa Kolbasina, Natalya A. Gureev, Artem P. Serzhantova, Olga V. Mikhailov, Andrey A. Moshurov, Ivan P. Starkov, Anatoly A. Popov, Vasily N. Heliyon Article We have shown that the H(2)O(2) concentration in exhaled breath condensate (EBC) in lung cancer patients increases significantly compared to the EBC of healthy people and revealed the correlation between the H(2)O(2) level in the EBC and amount of mtDNA damage in buccal mucosa cells. The H(2)O(2) hyper-production may trigger mitochondrial biogenesis, thereby resulting in an increase in mtDNA copy number. However, we did not observe a significant difference in the studied parameters between smokers and non-smokers. Overall, our data suggest that H(2)O(2) concentration in the EBC, the extent of mtDNA damage, and mtDNA copy number in buccal mucosa could be potential as an early diagnostic marker of lung cancer. Elsevier 2020-06-28 /pmc/articles/PMC7327746/ /pubmed/32637695 http://dx.doi.org/10.1016/j.heliyon.2020.e04303 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kolbasina, Natalya A.
Gureev, Artem P.
Serzhantova, Olga V.
Mikhailov, Andrey A.
Moshurov, Ivan P.
Starkov, Anatoly A.
Popov, Vasily N.
Lung cancer increases H(2)O(2) concentration in the exhaled breath condensate, extent of mtDNA damage, and mtDNA copy number in buccal mucosa
title Lung cancer increases H(2)O(2) concentration in the exhaled breath condensate, extent of mtDNA damage, and mtDNA copy number in buccal mucosa
title_full Lung cancer increases H(2)O(2) concentration in the exhaled breath condensate, extent of mtDNA damage, and mtDNA copy number in buccal mucosa
title_fullStr Lung cancer increases H(2)O(2) concentration in the exhaled breath condensate, extent of mtDNA damage, and mtDNA copy number in buccal mucosa
title_full_unstemmed Lung cancer increases H(2)O(2) concentration in the exhaled breath condensate, extent of mtDNA damage, and mtDNA copy number in buccal mucosa
title_short Lung cancer increases H(2)O(2) concentration in the exhaled breath condensate, extent of mtDNA damage, and mtDNA copy number in buccal mucosa
title_sort lung cancer increases h(2)o(2) concentration in the exhaled breath condensate, extent of mtdna damage, and mtdna copy number in buccal mucosa
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327746/
https://www.ncbi.nlm.nih.gov/pubmed/32637695
http://dx.doi.org/10.1016/j.heliyon.2020.e04303
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