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Redox dual-stimuli responsive drug delivery systems for improving tumor-targeting ability and reducing adverse side effects
Cancer is a big challenge that has plagued the human beings for ages and one of the most effective treatments is chemotherapy. However, the low tumor-targeting ability limits the wide clinical application of chemotherapy. The microenvironment plays a critical role in many aspects of tumor genesis. I...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shenyang Pharmaceutical University
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327776/ https://www.ncbi.nlm.nih.gov/pubmed/32636949 http://dx.doi.org/10.1016/j.ajps.2019.06.003 |
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author | Li, Ruirui Peng, Feifei Cai, Jia Yang, Dandan Zhang, Peng |
author_facet | Li, Ruirui Peng, Feifei Cai, Jia Yang, Dandan Zhang, Peng |
author_sort | Li, Ruirui |
collection | PubMed |
description | Cancer is a big challenge that has plagued the human beings for ages and one of the most effective treatments is chemotherapy. However, the low tumor-targeting ability limits the wide clinical application of chemotherapy. The microenvironment plays a critical role in many aspects of tumor genesis. It generates the tumor vasculature and it is highly implicated in the progression to metastasis. To maintain a suitable environment for tumor progression, there are special microenvironment in tumor cell, such as low pH, high level of glutathione (GSH) and reactive oxygen species (ROS), and more special enzymes, which is different to normal cell. Microenvironment-targeted therapy strategy could create new opportunities for therapeutic targeting. Compared to other targeting strategies, microenvironment-targeted therapy strategy will control the drug release into tumor cells more accurately. Redox responsive drug delivery systems (DDSs) are developed based on the high level of GSH in tumor cells. However, there are also GSH in normal cell though its level is lower. In order to control the release of drugs more accurately and reduce side effects, other drug release stimuli have been introduced to redox responsive DDSs. Under the synergistic reaction of two stimuli, redox dual-stimuli responsive DDSs will control the release of drugs more accurately and quickly and even increase the accumulation. This review summarizes strategies of redox dual-stimuli responsive DDSs such as pH, light, enzyme, ROS, and magnetic guide to delivery chemotherapeutic agents more accurately, aiming at providing new ideas for further promoting the drug release, enhancing tumor-targeting and improving anticancer effects. To better illustrate the redox dual-stimuli responsive DDS, preparations of carriers are also briefly described in the review. |
format | Online Article Text |
id | pubmed-7327776 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Shenyang Pharmaceutical University |
record_format | MEDLINE/PubMed |
spelling | pubmed-73277762020-07-06 Redox dual-stimuli responsive drug delivery systems for improving tumor-targeting ability and reducing adverse side effects Li, Ruirui Peng, Feifei Cai, Jia Yang, Dandan Zhang, Peng Asian J Pharm Sci Review article Cancer is a big challenge that has plagued the human beings for ages and one of the most effective treatments is chemotherapy. However, the low tumor-targeting ability limits the wide clinical application of chemotherapy. The microenvironment plays a critical role in many aspects of tumor genesis. It generates the tumor vasculature and it is highly implicated in the progression to metastasis. To maintain a suitable environment for tumor progression, there are special microenvironment in tumor cell, such as low pH, high level of glutathione (GSH) and reactive oxygen species (ROS), and more special enzymes, which is different to normal cell. Microenvironment-targeted therapy strategy could create new opportunities for therapeutic targeting. Compared to other targeting strategies, microenvironment-targeted therapy strategy will control the drug release into tumor cells more accurately. Redox responsive drug delivery systems (DDSs) are developed based on the high level of GSH in tumor cells. However, there are also GSH in normal cell though its level is lower. In order to control the release of drugs more accurately and reduce side effects, other drug release stimuli have been introduced to redox responsive DDSs. Under the synergistic reaction of two stimuli, redox dual-stimuli responsive DDSs will control the release of drugs more accurately and quickly and even increase the accumulation. This review summarizes strategies of redox dual-stimuli responsive DDSs such as pH, light, enzyme, ROS, and magnetic guide to delivery chemotherapeutic agents more accurately, aiming at providing new ideas for further promoting the drug release, enhancing tumor-targeting and improving anticancer effects. To better illustrate the redox dual-stimuli responsive DDS, preparations of carriers are also briefly described in the review. Shenyang Pharmaceutical University 2020-05 2019-08-21 /pmc/articles/PMC7327776/ /pubmed/32636949 http://dx.doi.org/10.1016/j.ajps.2019.06.003 Text en © 2019 Published by Elsevier B.V. on behalf of Shenyang Pharmaceutical University. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review article Li, Ruirui Peng, Feifei Cai, Jia Yang, Dandan Zhang, Peng Redox dual-stimuli responsive drug delivery systems for improving tumor-targeting ability and reducing adverse side effects |
title | Redox dual-stimuli responsive drug delivery systems for improving tumor-targeting ability and reducing adverse side effects |
title_full | Redox dual-stimuli responsive drug delivery systems for improving tumor-targeting ability and reducing adverse side effects |
title_fullStr | Redox dual-stimuli responsive drug delivery systems for improving tumor-targeting ability and reducing adverse side effects |
title_full_unstemmed | Redox dual-stimuli responsive drug delivery systems for improving tumor-targeting ability and reducing adverse side effects |
title_short | Redox dual-stimuli responsive drug delivery systems for improving tumor-targeting ability and reducing adverse side effects |
title_sort | redox dual-stimuli responsive drug delivery systems for improving tumor-targeting ability and reducing adverse side effects |
topic | Review article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327776/ https://www.ncbi.nlm.nih.gov/pubmed/32636949 http://dx.doi.org/10.1016/j.ajps.2019.06.003 |
work_keys_str_mv | AT liruirui redoxdualstimuliresponsivedrugdeliverysystemsforimprovingtumortargetingabilityandreducingadversesideeffects AT pengfeifei redoxdualstimuliresponsivedrugdeliverysystemsforimprovingtumortargetingabilityandreducingadversesideeffects AT caijia redoxdualstimuliresponsivedrugdeliverysystemsforimprovingtumortargetingabilityandreducingadversesideeffects AT yangdandan redoxdualstimuliresponsivedrugdeliverysystemsforimprovingtumortargetingabilityandreducingadversesideeffects AT zhangpeng redoxdualstimuliresponsivedrugdeliverysystemsforimprovingtumortargetingabilityandreducingadversesideeffects |