Hyperexcitable Parvalbumin Interneurons Render Hippocampal Circuitry Vulnerable to Amyloid Beta

Parvalbumin (PV) interneuron dysfunction is associated with various brain disorders, including Alzheimer disease (AD). Here, we asked whether early PV neuron hyperexcitability primes the hippocampus for amyloid beta-induced functional impairment. We show that prolonged chemogenetic activation of PV...

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Detalles Bibliográficos
Autores principales: Hijazi, Sara, Heistek, Tim S., van der Loo, Rolinka, Mansvelder, Huibert D., Smit, August B., van Kesteren, Ronald E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327841/
https://www.ncbi.nlm.nih.gov/pubmed/32593000
http://dx.doi.org/10.1016/j.isci.2020.101271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327841/
https://www.ncbi.nlm.nih.gov/pubmed/32593000
http://dx.doi.org/10.1016/j.isci.2020.101271

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