Transmissible Cancers in an Evolutionary Perspective

Inter-individual transmission of cancer cells represents an intriguing and unexplored host-pathogen system, with significant ecological and evolutionary ramifications. The pathogen consists of clonal malignant cell lines that spread horizontally as allografts and/or xenografts. Although only nine tr...

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Autores principales: Dujon, Antoine M., Gatenby, Robert A., Bramwell, Georgina, MacDonald, Nick, Dohrmann, Erin, Raven, Nynke, Schultz, Aaron, Hamede, Rodrigo, Gérard, Anne-Lise, Giraudeau, Mathieu, Thomas, Frédéric, Ujvari, Beata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327844/
https://www.ncbi.nlm.nih.gov/pubmed/32592998
http://dx.doi.org/10.1016/j.isci.2020.101269
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author Dujon, Antoine M.
Gatenby, Robert A.
Bramwell, Georgina
MacDonald, Nick
Dohrmann, Erin
Raven, Nynke
Schultz, Aaron
Hamede, Rodrigo
Gérard, Anne-Lise
Giraudeau, Mathieu
Thomas, Frédéric
Ujvari, Beata
author_facet Dujon, Antoine M.
Gatenby, Robert A.
Bramwell, Georgina
MacDonald, Nick
Dohrmann, Erin
Raven, Nynke
Schultz, Aaron
Hamede, Rodrigo
Gérard, Anne-Lise
Giraudeau, Mathieu
Thomas, Frédéric
Ujvari, Beata
author_sort Dujon, Antoine M.
collection PubMed
description Inter-individual transmission of cancer cells represents an intriguing and unexplored host-pathogen system, with significant ecological and evolutionary ramifications. The pathogen consists of clonal malignant cell lines that spread horizontally as allografts and/or xenografts. Although only nine transmissible cancer lineages in eight host species from both terrestrial and marine environments have been investigated, they exhibit evolutionary dynamics that may provide novel insights into tumor-host interactions particularly in the formation of metastases. Here we present an overview of known transmissible cancers, discuss the necessary and sufficient conditions for cancer transmission, and provide a comprehensive review on the evolutionary dynamics between transmissible cancers and their hosts.
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spelling pubmed-73278442020-07-06 Transmissible Cancers in an Evolutionary Perspective Dujon, Antoine M. Gatenby, Robert A. Bramwell, Georgina MacDonald, Nick Dohrmann, Erin Raven, Nynke Schultz, Aaron Hamede, Rodrigo Gérard, Anne-Lise Giraudeau, Mathieu Thomas, Frédéric Ujvari, Beata iScience Review Inter-individual transmission of cancer cells represents an intriguing and unexplored host-pathogen system, with significant ecological and evolutionary ramifications. The pathogen consists of clonal malignant cell lines that spread horizontally as allografts and/or xenografts. Although only nine transmissible cancer lineages in eight host species from both terrestrial and marine environments have been investigated, they exhibit evolutionary dynamics that may provide novel insights into tumor-host interactions particularly in the formation of metastases. Here we present an overview of known transmissible cancers, discuss the necessary and sufficient conditions for cancer transmission, and provide a comprehensive review on the evolutionary dynamics between transmissible cancers and their hosts. Elsevier 2020-06-12 /pmc/articles/PMC7327844/ /pubmed/32592998 http://dx.doi.org/10.1016/j.isci.2020.101269 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Dujon, Antoine M.
Gatenby, Robert A.
Bramwell, Georgina
MacDonald, Nick
Dohrmann, Erin
Raven, Nynke
Schultz, Aaron
Hamede, Rodrigo
Gérard, Anne-Lise
Giraudeau, Mathieu
Thomas, Frédéric
Ujvari, Beata
Transmissible Cancers in an Evolutionary Perspective
title Transmissible Cancers in an Evolutionary Perspective
title_full Transmissible Cancers in an Evolutionary Perspective
title_fullStr Transmissible Cancers in an Evolutionary Perspective
title_full_unstemmed Transmissible Cancers in an Evolutionary Perspective
title_short Transmissible Cancers in an Evolutionary Perspective
title_sort transmissible cancers in an evolutionary perspective
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327844/
https://www.ncbi.nlm.nih.gov/pubmed/32592998
http://dx.doi.org/10.1016/j.isci.2020.101269
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