Cargando…

Atypical spatial frequency dependence of visual metacognition among schizophrenia patients

Although altered early stages of visual processing have been reported among schizophrenia patients, how such atypical visual processing may affect higher-level cognition remains largely unknown. Here we tested the hypothesis that metacognitive performance may be atypically modulated by spatial frequ...

Descripción completa

Detalles Bibliográficos
Autores principales: Koizumi, Ai, Hori, Tomoki, Maniscalco, Brian, Hayase, Makoto, Mishima, Ryou, Kawashima, Takahiko, Miyata, Jun, Aso, Toshihiko, Lau, Hakwan, Takahashi, Hidehiko, Amano, Kaoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327871/
https://www.ncbi.nlm.nih.gov/pubmed/32599551
http://dx.doi.org/10.1016/j.nicl.2020.102296
_version_ 1783552637375873024
author Koizumi, Ai
Hori, Tomoki
Maniscalco, Brian
Hayase, Makoto
Mishima, Ryou
Kawashima, Takahiko
Miyata, Jun
Aso, Toshihiko
Lau, Hakwan
Takahashi, Hidehiko
Amano, Kaoru
author_facet Koizumi, Ai
Hori, Tomoki
Maniscalco, Brian
Hayase, Makoto
Mishima, Ryou
Kawashima, Takahiko
Miyata, Jun
Aso, Toshihiko
Lau, Hakwan
Takahashi, Hidehiko
Amano, Kaoru
author_sort Koizumi, Ai
collection PubMed
description Although altered early stages of visual processing have been reported among schizophrenia patients, how such atypical visual processing may affect higher-level cognition remains largely unknown. Here we tested the hypothesis that metacognitive performance may be atypically modulated by spatial frequency (SF) of visual stimuli among individuals with schizophrenia, given their altered magnocellular function. To study the effect of SF on metacognitive performance, we asked patients and controls to perform a visual detection task on gratings with different SFs and report confidence, and analyzed the data using the signal detection theoretic measure meta-d′. Control subjects showed better metacognitive performance after yes- (stimulus presence) than after no- (stimulus absence) responses (‘yes-response advantage’) for high SF (HSF) stimuli but not for low SF (LSF) stimuli. The patients, to the contrary, showed a ‘yes-response advantage’ not only for HSF but also for LSF stimuli, indicating atypical SF dependency of metacognition. An fMRI experiment using the same task revealed that the dorsolateral prefrontal cortex (DLPFC), known to be crucial for metacognition, shows activity mirroring the behavioral results: decoding accuracy of perceptual confidence in DLPFC was significantly higher for HSF than for LSF stimuli in controls, whereas this decoding accuracy was independent of SF in patients. Additionally, the functional connectivity of DLPFC with parietal and visual areas was modulated by SF and response type (yes/no) in a different manner between controls and patients. While individuals without schizophrenia may flexibly adapt metacognitive computations across SF ranges, patients may employ a different mechanism that is independent of SF. Because visual stimuli of low SF have been linked to predictive top-down processing, this may reflect atypical functioning in these processes in schizophrenia.
format Online
Article
Text
id pubmed-7327871
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-73278712020-07-06 Atypical spatial frequency dependence of visual metacognition among schizophrenia patients Koizumi, Ai Hori, Tomoki Maniscalco, Brian Hayase, Makoto Mishima, Ryou Kawashima, Takahiko Miyata, Jun Aso, Toshihiko Lau, Hakwan Takahashi, Hidehiko Amano, Kaoru Neuroimage Clin Regular Article Although altered early stages of visual processing have been reported among schizophrenia patients, how such atypical visual processing may affect higher-level cognition remains largely unknown. Here we tested the hypothesis that metacognitive performance may be atypically modulated by spatial frequency (SF) of visual stimuli among individuals with schizophrenia, given their altered magnocellular function. To study the effect of SF on metacognitive performance, we asked patients and controls to perform a visual detection task on gratings with different SFs and report confidence, and analyzed the data using the signal detection theoretic measure meta-d′. Control subjects showed better metacognitive performance after yes- (stimulus presence) than after no- (stimulus absence) responses (‘yes-response advantage’) for high SF (HSF) stimuli but not for low SF (LSF) stimuli. The patients, to the contrary, showed a ‘yes-response advantage’ not only for HSF but also for LSF stimuli, indicating atypical SF dependency of metacognition. An fMRI experiment using the same task revealed that the dorsolateral prefrontal cortex (DLPFC), known to be crucial for metacognition, shows activity mirroring the behavioral results: decoding accuracy of perceptual confidence in DLPFC was significantly higher for HSF than for LSF stimuli in controls, whereas this decoding accuracy was independent of SF in patients. Additionally, the functional connectivity of DLPFC with parietal and visual areas was modulated by SF and response type (yes/no) in a different manner between controls and patients. While individuals without schizophrenia may flexibly adapt metacognitive computations across SF ranges, patients may employ a different mechanism that is independent of SF. Because visual stimuli of low SF have been linked to predictive top-down processing, this may reflect atypical functioning in these processes in schizophrenia. Elsevier 2020-05-26 /pmc/articles/PMC7327871/ /pubmed/32599551 http://dx.doi.org/10.1016/j.nicl.2020.102296 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Koizumi, Ai
Hori, Tomoki
Maniscalco, Brian
Hayase, Makoto
Mishima, Ryou
Kawashima, Takahiko
Miyata, Jun
Aso, Toshihiko
Lau, Hakwan
Takahashi, Hidehiko
Amano, Kaoru
Atypical spatial frequency dependence of visual metacognition among schizophrenia patients
title Atypical spatial frequency dependence of visual metacognition among schizophrenia patients
title_full Atypical spatial frequency dependence of visual metacognition among schizophrenia patients
title_fullStr Atypical spatial frequency dependence of visual metacognition among schizophrenia patients
title_full_unstemmed Atypical spatial frequency dependence of visual metacognition among schizophrenia patients
title_short Atypical spatial frequency dependence of visual metacognition among schizophrenia patients
title_sort atypical spatial frequency dependence of visual metacognition among schizophrenia patients
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327871/
https://www.ncbi.nlm.nih.gov/pubmed/32599551
http://dx.doi.org/10.1016/j.nicl.2020.102296
work_keys_str_mv AT koizumiai atypicalspatialfrequencydependenceofvisualmetacognitionamongschizophreniapatients
AT horitomoki atypicalspatialfrequencydependenceofvisualmetacognitionamongschizophreniapatients
AT maniscalcobrian atypicalspatialfrequencydependenceofvisualmetacognitionamongschizophreniapatients
AT hayasemakoto atypicalspatialfrequencydependenceofvisualmetacognitionamongschizophreniapatients
AT mishimaryou atypicalspatialfrequencydependenceofvisualmetacognitionamongschizophreniapatients
AT kawashimatakahiko atypicalspatialfrequencydependenceofvisualmetacognitionamongschizophreniapatients
AT miyatajun atypicalspatialfrequencydependenceofvisualmetacognitionamongschizophreniapatients
AT asotoshihiko atypicalspatialfrequencydependenceofvisualmetacognitionamongschizophreniapatients
AT lauhakwan atypicalspatialfrequencydependenceofvisualmetacognitionamongschizophreniapatients
AT takahashihidehiko atypicalspatialfrequencydependenceofvisualmetacognitionamongschizophreniapatients
AT amanokaoru atypicalspatialfrequencydependenceofvisualmetacognitionamongschizophreniapatients