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SPC25 may promote proliferation and metastasis of hepatocellular carcinoma via p53
Hepatocellular carcinoma (HCC) is a common malignancy with poor prognosis and high mortality. To identify key genes associated with HCC and the underlying mechanisms, we performed weighted correlation network analysis (WGCNA) of potential key genes of HCC. We identified 17 key genes closely related...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327911/ https://www.ncbi.nlm.nih.gov/pubmed/32351050 http://dx.doi.org/10.1002/2211-5463.12872 |
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author | Chen, Fengjuan Zhang, Ka Huang, Yilin Luo, Fang Hu, Kunpeng Cai, Qingxian |
author_facet | Chen, Fengjuan Zhang, Ka Huang, Yilin Luo, Fang Hu, Kunpeng Cai, Qingxian |
author_sort | Chen, Fengjuan |
collection | PubMed |
description | Hepatocellular carcinoma (HCC) is a common malignancy with poor prognosis and high mortality. To identify key genes associated with HCC and the underlying mechanisms, we performed weighted correlation network analysis (WGCNA) of potential key genes of HCC. We identified 17 key genes closely related to HCC by yellow module combined with PPI analysis. Verification of the role of these genes revealed that SPC25 knockdown results in a significant decrease in proliferation and metastasis of HCC cells and increased protein levels of components of the p53 pathway in vitro. In summary, we identified that SPC25 is a potential tumor‐promoting factor in HCC and may act via the p53 pathway. |
format | Online Article Text |
id | pubmed-7327911 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73279112020-07-02 SPC25 may promote proliferation and metastasis of hepatocellular carcinoma via p53 Chen, Fengjuan Zhang, Ka Huang, Yilin Luo, Fang Hu, Kunpeng Cai, Qingxian FEBS Open Bio Research Articles Hepatocellular carcinoma (HCC) is a common malignancy with poor prognosis and high mortality. To identify key genes associated with HCC and the underlying mechanisms, we performed weighted correlation network analysis (WGCNA) of potential key genes of HCC. We identified 17 key genes closely related to HCC by yellow module combined with PPI analysis. Verification of the role of these genes revealed that SPC25 knockdown results in a significant decrease in proliferation and metastasis of HCC cells and increased protein levels of components of the p53 pathway in vitro. In summary, we identified that SPC25 is a potential tumor‐promoting factor in HCC and may act via the p53 pathway. John Wiley and Sons Inc. 2020-06-07 /pmc/articles/PMC7327911/ /pubmed/32351050 http://dx.doi.org/10.1002/2211-5463.12872 Text en © 2020 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Chen, Fengjuan Zhang, Ka Huang, Yilin Luo, Fang Hu, Kunpeng Cai, Qingxian SPC25 may promote proliferation and metastasis of hepatocellular carcinoma via p53 |
title | SPC25 may promote proliferation and metastasis of hepatocellular carcinoma via p53 |
title_full | SPC25 may promote proliferation and metastasis of hepatocellular carcinoma via p53 |
title_fullStr | SPC25 may promote proliferation and metastasis of hepatocellular carcinoma via p53 |
title_full_unstemmed | SPC25 may promote proliferation and metastasis of hepatocellular carcinoma via p53 |
title_short | SPC25 may promote proliferation and metastasis of hepatocellular carcinoma via p53 |
title_sort | spc25 may promote proliferation and metastasis of hepatocellular carcinoma via p53 |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327911/ https://www.ncbi.nlm.nih.gov/pubmed/32351050 http://dx.doi.org/10.1002/2211-5463.12872 |
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