Ferrous but not ferric iron sulfate kills photoreceptors and induces photoreceptor-dependent RPE autofluorescence

Iron has been implicated in the pathogenesis of retinal degenerative diseases, including ocular siderosis. However, the mechanisms of iron-induced retinal toxicity are incompletely understood. Previous work shows that intravitreal injection of Fe(2+) leads to photoreceptor (PR) oxidative stress, res...

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Detalles Bibliográficos
Autores principales: Shu, Wanting, Baumann, Bailey H., Song, Ying, Liu, Yingrui, Wu, Xingwei, Dunaief, Joshua L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Articles from the Special Issue on Oxidative stress in retina and retinal pigment epithelium in health and disease; Edited by Vera Bonilha
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327978/
https://www.ncbi.nlm.nih.gov/pubmed/32362442
http://dx.doi.org/10.1016/j.redox.2020.101469

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