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Default network interactivity during mentalizing about known others is modulated by age and social closeness
In young adults, mentalizing about known others engages the default network, with differential brain response modulated by social closeness. While the functional integrity of the default network changes with age, few studies have investigated how these changes impact the representation of known othe...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328027/ https://www.ncbi.nlm.nih.gov/pubmed/32399555 http://dx.doi.org/10.1093/scan/nsaa067 |
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author | Laurita, Anne C DuPre, Elizabeth Ebner, Natalie C Turner, Gary R Spreng, R Nathan |
author_facet | Laurita, Anne C DuPre, Elizabeth Ebner, Natalie C Turner, Gary R Spreng, R Nathan |
author_sort | Laurita, Anne C |
collection | PubMed |
description | In young adults, mentalizing about known others engages the default network, with differential brain response modulated by social closeness. While the functional integrity of the default network changes with age, few studies have investigated how these changes impact the representation of known others, across levels of closeness. Young (N = 29, 16 females) and older (N = 27, 12 females) adults underwent functional magnetic resonance imaging (fMRI) scanning while making trait judgments for social others varying in closeness. Multivariate analyses (partial least squares) identified default network activation for trait judgments across both age cohorts. For young adults, romantic partner and self-judgments differed from other levels of social closeness and were associated with activity in default and salience networks. In contrast, default network interactivity was not modulated by social closeness for older adults. In two functional connectivity analyses, both age groups demonstrated connectivity between dorsal and ventral medial prefrontal cortex and other default network regions during trait judgments. However older, but not young, adults also showed increased functional coupling between medial and lateral prefrontal brain regions that did not vary by category of known other. Mentalizing about others engages default and frontal brain regions in older adulthood, and this coupling is poorly modulated by social closeness. |
format | Online Article Text |
id | pubmed-7328027 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-73280272020-07-15 Default network interactivity during mentalizing about known others is modulated by age and social closeness Laurita, Anne C DuPre, Elizabeth Ebner, Natalie C Turner, Gary R Spreng, R Nathan Soc Cogn Affect Neurosci Original Article In young adults, mentalizing about known others engages the default network, with differential brain response modulated by social closeness. While the functional integrity of the default network changes with age, few studies have investigated how these changes impact the representation of known others, across levels of closeness. Young (N = 29, 16 females) and older (N = 27, 12 females) adults underwent functional magnetic resonance imaging (fMRI) scanning while making trait judgments for social others varying in closeness. Multivariate analyses (partial least squares) identified default network activation for trait judgments across both age cohorts. For young adults, romantic partner and self-judgments differed from other levels of social closeness and were associated with activity in default and salience networks. In contrast, default network interactivity was not modulated by social closeness for older adults. In two functional connectivity analyses, both age groups demonstrated connectivity between dorsal and ventral medial prefrontal cortex and other default network regions during trait judgments. However older, but not young, adults also showed increased functional coupling between medial and lateral prefrontal brain regions that did not vary by category of known other. Mentalizing about others engages default and frontal brain regions in older adulthood, and this coupling is poorly modulated by social closeness. Oxford University Press 2020-05-13 /pmc/articles/PMC7328027/ /pubmed/32399555 http://dx.doi.org/10.1093/scan/nsaa067 Text en © The Author(s) 2020. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Laurita, Anne C DuPre, Elizabeth Ebner, Natalie C Turner, Gary R Spreng, R Nathan Default network interactivity during mentalizing about known others is modulated by age and social closeness |
title | Default network interactivity during mentalizing about known others is modulated by age and social closeness |
title_full | Default network interactivity during mentalizing about known others is modulated by age and social closeness |
title_fullStr | Default network interactivity during mentalizing about known others is modulated by age and social closeness |
title_full_unstemmed | Default network interactivity during mentalizing about known others is modulated by age and social closeness |
title_short | Default network interactivity during mentalizing about known others is modulated by age and social closeness |
title_sort | default network interactivity during mentalizing about known others is modulated by age and social closeness |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328027/ https://www.ncbi.nlm.nih.gov/pubmed/32399555 http://dx.doi.org/10.1093/scan/nsaa067 |
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