Calcium-Sensing Receptor Mediates β-Amyloid-Induced Synaptic Formation Impairment and Cognitive Deficits via Regulation of Cytosolic Phospholipase A2/Prostaglandin E2 Metabolic Pathway

Calcium-sensing receptor (CaSR) is a G protein-coupled receptor (GPCRs). Soluble β-amyloid peptide (Aβ) is one of the orthosteric modulators of CaSR, while, the role and underlying mechanism of CaSR in cognitive decline in Alzheimer’s disease (AD) is unclear. In this study, molecular technology such...

Descripción completa

Detalles Bibliográficos
Autores principales: Feng, Chenxi, Bao, Xiaoming, Shan, Ling, Ling, Yunxiang, Ding, Yanfei, Wang, Jia, Cao, Yanzi, Wang, Qinwen, Cui, Wei, Xu, Shujun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328130/
https://www.ncbi.nlm.nih.gov/pubmed/32670047
http://dx.doi.org/10.3389/fnagi.2020.00144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328130/
https://www.ncbi.nlm.nih.gov/pubmed/32670047
http://dx.doi.org/10.3389/fnagi.2020.00144

Ejemplares similares