Simulating ComBat: how batch correction can lead to the systematic introduction of false positive results in DNA methylation microarray studies

BACKGROUND: Systematic technical effects—also called batch effects—are a considerable challenge when analyzing DNA methylation (DNAm) microarray data, because they can lead to false results when confounded with the variable of interest. Methods to correct these batch effects are error-prone, as prev...

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Detalles Bibliográficos
Autores principales: Zindler, Tristan, Frieling, Helge, Neyazi, Alexandra, Bleich, Stefan, Friedel, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328269/
https://www.ncbi.nlm.nih.gov/pubmed/32605541
http://dx.doi.org/10.1186/s12859-020-03559-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328269/
https://www.ncbi.nlm.nih.gov/pubmed/32605541
http://dx.doi.org/10.1186/s12859-020-03559-6

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