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Simulating ComBat: how batch correction can lead to the systematic introduction of false positive results in DNA methylation microarray studies
BACKGROUND: Systematic technical effects—also called batch effects—are a considerable challenge when analyzing DNA methylation (DNAm) microarray data, because they can lead to false results when confounded with the variable of interest. Methods to correct these batch effects are error-prone, as prev...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328269/ https://www.ncbi.nlm.nih.gov/pubmed/32605541 http://dx.doi.org/10.1186/s12859-020-03559-6 |