A genome-wide and cotranscriptional suppressor of R loops

R loops arise from hybridization of RNA transcripts with template DNA during transcription. Unrepaired R loops lead to transcription–replication collisions, causing DNA damage and genomic instability. In this issue of Genes & Development, Pérez-Calero and colleagues (pp. 898–912) identify UAP56...

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Detalles Bibliográficos
Autores principales: Matson, Jacob P., Zou, Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Outlook
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328514/
https://www.ncbi.nlm.nih.gov/pubmed/32611612
http://dx.doi.org/10.1101/gad.339861.120
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author Matson, Jacob P.
Zou, Lee
author_facet Matson, Jacob P.
Zou, Lee
author_sort Matson, Jacob P.
collection PubMed
description R loops arise from hybridization of RNA transcripts with template DNA during transcription. Unrepaired R loops lead to transcription–replication collisions, causing DNA damage and genomic instability. In this issue of Genes & Development, Pérez-Calero and colleagues (pp. 898–912) identify UAP56 as a cotranscriptional RNA–DNA helicase that unwinds R loops. They found that UAP56 helicase activity is required to remove R loops formed from different sources and prevent R-loop accumulation genome-wide at actively transcribed genes.
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spelling pubmed-73285142021-01-01 A genome-wide and cotranscriptional suppressor of R loops Matson, Jacob P. Zou, Lee Genes Dev Outlook R loops arise from hybridization of RNA transcripts with template DNA during transcription. Unrepaired R loops lead to transcription–replication collisions, causing DNA damage and genomic instability. In this issue of Genes & Development, Pérez-Calero and colleagues (pp. 898–912) identify UAP56 as a cotranscriptional RNA–DNA helicase that unwinds R loops. They found that UAP56 helicase activity is required to remove R loops formed from different sources and prevent R-loop accumulation genome-wide at actively transcribed genes. Cold Spring Harbor Laboratory Press 2020-07-01 /pmc/articles/PMC7328514/ /pubmed/32611612 http://dx.doi.org/10.1101/gad.339861.120 Text en © 2020 Matson and Zou; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Outlook
Matson, Jacob P.
Zou, Lee
A genome-wide and cotranscriptional suppressor of R loops
title A genome-wide and cotranscriptional suppressor of R loops
title_full A genome-wide and cotranscriptional suppressor of R loops
title_fullStr A genome-wide and cotranscriptional suppressor of R loops
title_full_unstemmed A genome-wide and cotranscriptional suppressor of R loops
title_short A genome-wide and cotranscriptional suppressor of R loops
title_sort genome-wide and cotranscriptional suppressor of r loops
topic Outlook
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328514/
https://www.ncbi.nlm.nih.gov/pubmed/32611612
http://dx.doi.org/10.1101/gad.339861.120
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