Cargando…

Yeast-based assays for the functional characterization of cancer-associated variants of human DNA repair genes

Technological advances are continuously revealing new genetic variants that are often difficult to interpret. As one of the most genetically tractable model organisms, yeast can have a central role in determining the consequences of human genetic variation. DNA repair gene mutations are associated w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cervelli, Tiziana, Lodovichi, Samuele, Bellè, Francesca, Galli, Alvaro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Shared Science Publishers OG 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328678/ https://www.ncbi.nlm.nih.gov/pubmed/32656256 http://dx.doi.org/10.15698/mic2020.07.721

Ejemplares similares

Validation and Data-Integration of Yeast-Based Assays for Functional Classification of BRCA1 Missense Variants
por: Bellè, Francesca, et al.
Publicado: (2022)

Inhibition of DNA Repair in Cancer Therapy: Toward a Multi-Target Approach
por: Lodovichi, Samuele, et al.
Publicado: (2020)

Computational analysis of data from a genome-wide screening identifies new PARP1 functional interactors as potential therapeutic targets
por: Lodovichi, Samuele, et al.
Publicado: (2019)

Yeast as a Tool to Understand the Significance of Human Disease-Associated Gene Variants
por: Cervelli, Tiziana, et al.
Publicado: (2021)

Functional Interaction Between BRCA1 and DNA Repair in Yeast May Uncover a Role of RAD50, RAD51, MRE11A, and MSH6 Somatic Variants in Cancer Development
por: Maresca, Luisa, et al.
Publicado: (2018)

Yeast-based assays for characterization of the functional effects of single nucleotide polymorphisms in human DNA repair genes
por: Kim, Changshin, et al.
Publicado: (2018)

DNA Damage and Repair in Atherosclerosis: Current Insights and Future Perspectives
por: Cervelli, Tiziana, et al.
Publicado: (2012)

Identification of novel plant cysteine oxidase inhibitors from a yeast chemical genetic screen
por: Lavilla-Puerta, Mikel, et al.
Publicado: (2023)

The Over-expression of the β2 Catalytic Subunit of the Proteasome Decreases Homologous Recombination and Impairs DNA Double-Strand Break Repair in Human Cells
por: Collavoli, Anita, et al.
Publicado: (2011)

Rad9/53BP1 promotes DNA repair via crossover recombination by limiting the Sgs1 and Mph1 helicases
por: Ferrari, Matteo, et al.
Publicado: (2020)

Inverted terminal repeats of adeno-associated virus decrease random integration of a gene targeting fragment in Saccharomyces cerevisiae
por: Galli, Alvaro, et al.
Publicado: (2014)

Formation of AAV Single Stranded DNA Genome from a Circular Plasmid in Saccharomyces cerevisiae
por: Cervelli, Tiziana, et al.
Publicado: (2011)

Functional characterization of polymorphisms in DNA repair genes using cytogenetic challenge assays.
por: Au, William W, et al.
Publicado: (2003)

The pol3-t Hyperrecombination Phenotype and DNA Damage-Induced Recombination in Saccharomyces cerevisiae Is RAD50 Dependent
por: Galli, Alvaro, et al.
Publicado: (2009)

Potentiation of gene targeting in human cells by expression of Saccharomyces cerevisiae Rad52
por: Di Primio, Cristina, et al.
Publicado: (2005)

Screening the yeast genome for new DNA-repair genes
por: Jazayeri, Ali, et al.
Publicado: (2002)

Functional characterization of BRCA1 gene variants by mini-gene splicing assay
por: Steffensen, Ane Y, et al.
Publicado: (2014)

Functional Characterization of Argininosuccinate Lyase Gene Variants by Mini-Gene Splicing Assay
por: Wang, Yanyun, et al.
Publicado: (2019)

The Chromatin Landscape around DNA Double-Strand Breaks in Yeast and Its Influence on DNA Repair Pathway Choice
por: Frigerio, Chiara, et al.
Publicado: (2023)

Impact of DNA-binding position variants on yeast gene expression
por: Swamy, Krishna B. S., et al.
Publicado: (2009)

Determining the functional significance of mismatch repair gene missense variants using biochemical and cellular assays
por: Heinen, Christopher D, et al.
Publicado: (2012)

Limited DNA Repair Gene Repertoire in Ascomycete Yeast Revealed by Comparative Genomics
por: Milo, Shira, et al.
Publicado: (2019)

Functional genomics of the yeast DNA-damage response
por: Cagney, Gerard, et al.
Publicado: (2006)

Yeast expression of mammalian Onzin and fungal FCR1 suggests ancestral functions of PLAC8 proteins in mitochondrial metabolism and DNA repair
por: Daghino, Stefania, et al.
Publicado: (2019)

Detection of Germline Variants in 450 Breast/Ovarian Cancer Families with a Multi-Gene Panel Including Coding and Regulatory Regions
por: Guglielmi, Chiara, et al.
Publicado: (2021)

Guidelines for DNA recombination and repair studies: Mechanistic assays of DNA repair processes
por: Klein, Hannah L, et al.
Publicado: (2019)

Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways
por: Klein, Hannah L., et al.
Publicado: (2019)

Complementation of Yeast Genes with Human Genes as an Experimental Platform for Functional Testing of Human Genetic Variants
por: Hamza, Akil, et al.
Publicado: (2015)

Functional Classification of BRCA2 DNA Variants by Splicing Assays in a Large Minigene with 9 Exons
por: Acedo, Alberto, et al.
Publicado: (2015)

Germline predisposition to pediatric Ewing sarcoma is characterized by inherited pathogenic variants in DNA damage repair genes
por: Gillani, Riaz, et al.
Publicado: (2022)

DNA Repair Molecular Beacon assay: a platform for real-time functional analysis of cellular DNA repair capacity
por: Li, Jianfeng, et al.
Publicado: (2018)

DNA Mismatch Repair Gene Variants in Sporadic Solid Cancers
por: Caja, Fabian, et al.
Publicado: (2020)

SNPs Altering Ammonium Transport Activity of Human Rhesus Factors Characterized by a Yeast-Based Functional Assay
por: Deschuyteneer, Aude, et al.
Publicado: (2013)

Variants of the human RAD52 gene confer defects in ionizing radiation resistance and homologous recombination repair in budding yeast
por: Clear, Alissa D., et al.
Publicado: (2020)

Network-based characterization and prediction of human DNA repair genes and pathways
por: Li, Yan-Hui, et al.
Publicado: (2017)

Extensive loss of cell-cycle and DNA repair genes in an ancient lineage of bipolar budding yeasts
por: Steenwyk, Jacob L., et al.
Publicado: (2019)

Isolation of human and murine hematopoietic stem cells for DNA damage and DNA repair assays
por: Rodríguez, Alfredo, et al.
Publicado: (2021)

Capsid protein expression and adeno-associated virus like particles assembly in Saccharomyces cerevisiae
por: Backovic, Ana, et al.
Publicado: (2012)

Yeast one-hybrid assays for gene-centered human gene regulatory network mapping
por: Reece-Hoyes, John S, et al.
Publicado: (2011)

Comet assay to measure DNA repair: approach and applications
por: Azqueta, Amaya, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_ort0njc1f4tmv6hgghh6nj168l