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Changes of retinal and choroidal capillary blood flow in macula after an acute intraocular pressure elevation

The aim of this study was to investigate the changes of retinal vessel density (VD) and choriocapillary blood flow area (CBFA) in macula after an acute intraocular pressure (IOP) elevation observed using optical coherence tomography angiography. This was a prospective comparative study of subjects w...

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Autores principales: Ma, Ziwei, Pan, Xuefeng, Zhou, Danni, Zhu, Zhuangzhi, Xu, Aiping, Shi, Peng, Chen, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328993/
https://www.ncbi.nlm.nih.gov/pubmed/32590817
http://dx.doi.org/10.1097/MD.0000000000021007
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author Ma, Ziwei
Pan, Xuefeng
Zhou, Danni
Zhu, Zhuangzhi
Xu, Aiping
Shi, Peng
Chen, Hong
author_facet Ma, Ziwei
Pan, Xuefeng
Zhou, Danni
Zhu, Zhuangzhi
Xu, Aiping
Shi, Peng
Chen, Hong
author_sort Ma, Ziwei
collection PubMed
description The aim of this study was to investigate the changes of retinal vessel density (VD) and choriocapillary blood flow area (CBFA) in macula after an acute intraocular pressure (IOP) elevation observed using optical coherence tomography angiography. This was a prospective comparative study of subjects with narrow anterior chamber angles who underwent laser peripheral iridotomies (LPIs). The IOP was measured before and 1 hour after the LPI. The retinal VDs and CBFAs of the macula were measured using optical coherence tomography angiography at the baseline and 1 hour after the LPI. A total of 88 eyes of 88 individuals were enrolled in our study, and 70 eyes of 70 individuals finally completed the study with a mean IOP rise of 10.2 ± 7.5 mm Hg after the LPI. The VDs and areas of foveal avascular zone of all of the subjects did not differ significantly between the measurements obtained at the baseline and 1 hour after the LPI (P > .05). However, there were statistically significant differences in the CBFAs at the baseline and 1 hour after the LPI (P < .05). Based on the magnitude of the rise in the IOP, we divided the subjects into three groups: group A = IOP rise ≤ 10 mm Hg, group B = 10 mm Hg < IOP rise ≤20 mm Hg, and group C = IOP rise > 20 mmHg. The VDs of the macula measured at the baseline were significantly different from the measurements obtained 1 hour after the LPI in group C in either the superficial retinal layer or deep retinal layer (P < .05). Compared with baseline, the CBFAs measured at 1 hour after the LPI were decreased in group B and group C (P < .05). In these subjects with narrow antenior chamber, the blood flow in macula began to be affected with the acute IOP rise greater than 10 mm Hg. It was confirmed that the retina and choroid showed some different ability to regulate its blood flow in response to changes in IOP.
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spelling pubmed-73289932020-07-09 Changes of retinal and choroidal capillary blood flow in macula after an acute intraocular pressure elevation Ma, Ziwei Pan, Xuefeng Zhou, Danni Zhu, Zhuangzhi Xu, Aiping Shi, Peng Chen, Hong Medicine (Baltimore) 5800 The aim of this study was to investigate the changes of retinal vessel density (VD) and choriocapillary blood flow area (CBFA) in macula after an acute intraocular pressure (IOP) elevation observed using optical coherence tomography angiography. This was a prospective comparative study of subjects with narrow anterior chamber angles who underwent laser peripheral iridotomies (LPIs). The IOP was measured before and 1 hour after the LPI. The retinal VDs and CBFAs of the macula were measured using optical coherence tomography angiography at the baseline and 1 hour after the LPI. A total of 88 eyes of 88 individuals were enrolled in our study, and 70 eyes of 70 individuals finally completed the study with a mean IOP rise of 10.2 ± 7.5 mm Hg after the LPI. The VDs and areas of foveal avascular zone of all of the subjects did not differ significantly between the measurements obtained at the baseline and 1 hour after the LPI (P > .05). However, there were statistically significant differences in the CBFAs at the baseline and 1 hour after the LPI (P < .05). Based on the magnitude of the rise in the IOP, we divided the subjects into three groups: group A = IOP rise ≤ 10 mm Hg, group B = 10 mm Hg < IOP rise ≤20 mm Hg, and group C = IOP rise > 20 mmHg. The VDs of the macula measured at the baseline were significantly different from the measurements obtained 1 hour after the LPI in group C in either the superficial retinal layer or deep retinal layer (P < .05). Compared with baseline, the CBFAs measured at 1 hour after the LPI were decreased in group B and group C (P < .05). In these subjects with narrow antenior chamber, the blood flow in macula began to be affected with the acute IOP rise greater than 10 mm Hg. It was confirmed that the retina and choroid showed some different ability to regulate its blood flow in response to changes in IOP. Wolters Kluwer Health 2020-06-26 /pmc/articles/PMC7328993/ /pubmed/32590817 http://dx.doi.org/10.1097/MD.0000000000021007 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 5800
Ma, Ziwei
Pan, Xuefeng
Zhou, Danni
Zhu, Zhuangzhi
Xu, Aiping
Shi, Peng
Chen, Hong
Changes of retinal and choroidal capillary blood flow in macula after an acute intraocular pressure elevation
title Changes of retinal and choroidal capillary blood flow in macula after an acute intraocular pressure elevation
title_full Changes of retinal and choroidal capillary blood flow in macula after an acute intraocular pressure elevation
title_fullStr Changes of retinal and choroidal capillary blood flow in macula after an acute intraocular pressure elevation
title_full_unstemmed Changes of retinal and choroidal capillary blood flow in macula after an acute intraocular pressure elevation
title_short Changes of retinal and choroidal capillary blood flow in macula after an acute intraocular pressure elevation
title_sort changes of retinal and choroidal capillary blood flow in macula after an acute intraocular pressure elevation
topic 5800
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328993/
https://www.ncbi.nlm.nih.gov/pubmed/32590817
http://dx.doi.org/10.1097/MD.0000000000021007
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