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Vortioxetine improves rapid eye movement sleep behavior disorder: A case report
RATIONALE: Rapid eye movement sleep behavior disorder (RBD) is a kind of sleep disturbance characterized by a loss of normal paralysis of REM sleep with dream enactment behavior during REM sleep. The pharmacotherapy options for treating RBD are limited and the use of antidepressants remains controve...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329003/ https://www.ncbi.nlm.nih.gov/pubmed/32590816 http://dx.doi.org/10.1097/MD.0000000000021003 |
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author | Du, Yanli Jiang, Jiajun Ng, Chee H. Wu, Lingling Zhang, Peifen Xi, Caixi Lai, Jianbo Xu, Yi Hu, Shaohua Wang, Zheng |
author_facet | Du, Yanli Jiang, Jiajun Ng, Chee H. Wu, Lingling Zhang, Peifen Xi, Caixi Lai, Jianbo Xu, Yi Hu, Shaohua Wang, Zheng |
author_sort | Du, Yanli |
collection | PubMed |
description | RATIONALE: Rapid eye movement sleep behavior disorder (RBD) is a kind of sleep disturbance characterized by a loss of normal paralysis of REM sleep with dream enactment behavior during REM sleep. The pharmacotherapy options for treating RBD are limited and the use of antidepressants remains controversial. Further, the role of vortioxetine in RBD has not been evaluated so far. PATIENT CONCERNS: A 72-year-old woman presented with recurrent peculiar behaviors such as shouting, punching, kicking or even walking around her bedroom during sleep for over 3 years. DIAGNOSIS: Clinical examinations and polysomnography indicated the diagnosis of RBD. INTERVENTIONS: The patient received treatment with paroxetine and melatonin for 1 year and then paroxetine was discontinued and vortioxetine was initiated in a daily dose of 10 mg. OUTCOMES: Treatment with paroxetine and melatonin for one year was ineffective. A trial of vortioxetine 10 mg per day over 3 months resulted in significant clinical improvement. LESSONS: To our knowledge, this is the first reported case of effective treatment of RBD with vortioxetine. Well-designed studies with large samples are needed to verify the clinical benefits. |
format | Online Article Text |
id | pubmed-7329003 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-73290032020-07-09 Vortioxetine improves rapid eye movement sleep behavior disorder: A case report Du, Yanli Jiang, Jiajun Ng, Chee H. Wu, Lingling Zhang, Peifen Xi, Caixi Lai, Jianbo Xu, Yi Hu, Shaohua Wang, Zheng Medicine (Baltimore) 6500 RATIONALE: Rapid eye movement sleep behavior disorder (RBD) is a kind of sleep disturbance characterized by a loss of normal paralysis of REM sleep with dream enactment behavior during REM sleep. The pharmacotherapy options for treating RBD are limited and the use of antidepressants remains controversial. Further, the role of vortioxetine in RBD has not been evaluated so far. PATIENT CONCERNS: A 72-year-old woman presented with recurrent peculiar behaviors such as shouting, punching, kicking or even walking around her bedroom during sleep for over 3 years. DIAGNOSIS: Clinical examinations and polysomnography indicated the diagnosis of RBD. INTERVENTIONS: The patient received treatment with paroxetine and melatonin for 1 year and then paroxetine was discontinued and vortioxetine was initiated in a daily dose of 10 mg. OUTCOMES: Treatment with paroxetine and melatonin for one year was ineffective. A trial of vortioxetine 10 mg per day over 3 months resulted in significant clinical improvement. LESSONS: To our knowledge, this is the first reported case of effective treatment of RBD with vortioxetine. Well-designed studies with large samples are needed to verify the clinical benefits. Wolters Kluwer Health 2020-06-26 /pmc/articles/PMC7329003/ /pubmed/32590816 http://dx.doi.org/10.1097/MD.0000000000021003 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 6500 Du, Yanli Jiang, Jiajun Ng, Chee H. Wu, Lingling Zhang, Peifen Xi, Caixi Lai, Jianbo Xu, Yi Hu, Shaohua Wang, Zheng Vortioxetine improves rapid eye movement sleep behavior disorder: A case report |
title | Vortioxetine improves rapid eye movement sleep behavior disorder: A case report |
title_full | Vortioxetine improves rapid eye movement sleep behavior disorder: A case report |
title_fullStr | Vortioxetine improves rapid eye movement sleep behavior disorder: A case report |
title_full_unstemmed | Vortioxetine improves rapid eye movement sleep behavior disorder: A case report |
title_short | Vortioxetine improves rapid eye movement sleep behavior disorder: A case report |
title_sort | vortioxetine improves rapid eye movement sleep behavior disorder: a case report |
topic | 6500 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329003/ https://www.ncbi.nlm.nih.gov/pubmed/32590816 http://dx.doi.org/10.1097/MD.0000000000021003 |
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