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Assessment of Pyloric Sphincter Physiology Using Functional Luminal Imaging Probe in Healthy Volunteers

BACKGROUND/AIMS: The functional luminal imaging probe (FLIP) can measure tissue distensibility and geometric changes through volumetric distention. The esophagogastric junction has been well studied using EndoFLIP, studies on pylorus are lacking. We aim to study biomechanical properties of pylorus u...

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Autores principales: Jagtap, Nitin, Kalapala, Rakesh, Reddy, D Nageshwar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Neurogastroenterology and Motility 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329157/
https://www.ncbi.nlm.nih.gov/pubmed/32606259
http://dx.doi.org/10.5056/jnm19200
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author Jagtap, Nitin
Kalapala, Rakesh
Reddy, D Nageshwar
author_facet Jagtap, Nitin
Kalapala, Rakesh
Reddy, D Nageshwar
author_sort Jagtap, Nitin
collection PubMed
description BACKGROUND/AIMS: The functional luminal imaging probe (FLIP) can measure tissue distensibility and geometric changes through volumetric distention. The esophagogastric junction has been well studied using EndoFLIP, studies on pylorus are lacking. We aim to study biomechanical properties of pylorus using EndoFLIP to create normative data. METHODS: We performed a prospective study of 20 healthy volunteers (ages, 18-54 years; 10 men) who underwent pylorus evaluation using 12-cm FLIP placed across the pyloric sphincter. FLIP data were analyzed using FLIP planimetry plots at baseline and after administration of hyoscine butyl bromide injection. RESULTS: The median pylorus distensibility index (P-DI) was 8.37 mm(2)/mmHg (interquartile range, 4.22-13.04 mm(2)/mmHg) at 40 mL balloon volume. The 90th percentile at 40 mL balloon for P-DI was 14.89 mm(2)/mmHg, for cross-sectional area was 244.20 mm(2)/mmHg, and diameter and pressure were 17.58 mm and 48.84 mmHg, respectively. There was significant increase in P-DI after administration of hyoscine butyl bromide injection (P < 0.05). CONCLUSION: The normative values can be used as reference values for pyloric distensibility. This reference can be used in studies of related to pyloric diseases such as gastroparesis.
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spelling pubmed-73291572020-07-10 Assessment of Pyloric Sphincter Physiology Using Functional Luminal Imaging Probe in Healthy Volunteers Jagtap, Nitin Kalapala, Rakesh Reddy, D Nageshwar J Neurogastroenterol Motil Original Article BACKGROUND/AIMS: The functional luminal imaging probe (FLIP) can measure tissue distensibility and geometric changes through volumetric distention. The esophagogastric junction has been well studied using EndoFLIP, studies on pylorus are lacking. We aim to study biomechanical properties of pylorus using EndoFLIP to create normative data. METHODS: We performed a prospective study of 20 healthy volunteers (ages, 18-54 years; 10 men) who underwent pylorus evaluation using 12-cm FLIP placed across the pyloric sphincter. FLIP data were analyzed using FLIP planimetry plots at baseline and after administration of hyoscine butyl bromide injection. RESULTS: The median pylorus distensibility index (P-DI) was 8.37 mm(2)/mmHg (interquartile range, 4.22-13.04 mm(2)/mmHg) at 40 mL balloon volume. The 90th percentile at 40 mL balloon for P-DI was 14.89 mm(2)/mmHg, for cross-sectional area was 244.20 mm(2)/mmHg, and diameter and pressure were 17.58 mm and 48.84 mmHg, respectively. There was significant increase in P-DI after administration of hyoscine butyl bromide injection (P < 0.05). CONCLUSION: The normative values can be used as reference values for pyloric distensibility. This reference can be used in studies of related to pyloric diseases such as gastroparesis. The Korean Society of Neurogastroenterology and Motility 2020-07-30 2020-07-30 /pmc/articles/PMC7329157/ /pubmed/32606259 http://dx.doi.org/10.5056/jnm19200 Text en © 2020 The Korean Society of Neurogastroenterology and Motility This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Jagtap, Nitin
Kalapala, Rakesh
Reddy, D Nageshwar
Assessment of Pyloric Sphincter Physiology Using Functional Luminal Imaging Probe in Healthy Volunteers
title Assessment of Pyloric Sphincter Physiology Using Functional Luminal Imaging Probe in Healthy Volunteers
title_full Assessment of Pyloric Sphincter Physiology Using Functional Luminal Imaging Probe in Healthy Volunteers
title_fullStr Assessment of Pyloric Sphincter Physiology Using Functional Luminal Imaging Probe in Healthy Volunteers
title_full_unstemmed Assessment of Pyloric Sphincter Physiology Using Functional Luminal Imaging Probe in Healthy Volunteers
title_short Assessment of Pyloric Sphincter Physiology Using Functional Luminal Imaging Probe in Healthy Volunteers
title_sort assessment of pyloric sphincter physiology using functional luminal imaging probe in healthy volunteers
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329157/
https://www.ncbi.nlm.nih.gov/pubmed/32606259
http://dx.doi.org/10.5056/jnm19200
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