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Brain states govern the spatio-temporal dynamics of resting-state functional connectivity
Previously, using simultaneous resting-state functional magnetic resonance imaging (fMRI) and photometry-based neuronal calcium recordings in the anesthetized rat, we identified blood oxygenation level-dependent (BOLD) responses directly related to slow calcium waves, revealing a cortex-wide and spa...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329332/ https://www.ncbi.nlm.nih.gov/pubmed/32568067 http://dx.doi.org/10.7554/eLife.53186 |
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author | Aedo-Jury, Felipe Schwalm, Miriam Hamzehpour, Lara Stroh, Albrecht |
author_facet | Aedo-Jury, Felipe Schwalm, Miriam Hamzehpour, Lara Stroh, Albrecht |
author_sort | Aedo-Jury, Felipe |
collection | PubMed |
description | Previously, using simultaneous resting-state functional magnetic resonance imaging (fMRI) and photometry-based neuronal calcium recordings in the anesthetized rat, we identified blood oxygenation level-dependent (BOLD) responses directly related to slow calcium waves, revealing a cortex-wide and spatially organized correlate of locally recorded neuronal activity (Schwalm et al., 2017). Here, using the same techniques, we investigate two distinct cortical activity states: persistent activity, in which compartmentalized network dynamics were observed; and slow wave activity, dominated by a cortex-wide BOLD component, suggesting a strong functional coupling of inter-cortical activity. During slow wave activity, we find a correlation between the occurring slow wave events and the strength of functional connectivity between different cortical areas. These findings suggest that down-up transitions of neuronal excitability can drive cortex-wide functional connectivity. This study provides further evidence that changes in functional connectivity are dependent on the brain’s current state, directly linked to the generation of slow waves. |
format | Online Article Text |
id | pubmed-7329332 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-73293322020-07-13 Brain states govern the spatio-temporal dynamics of resting-state functional connectivity Aedo-Jury, Felipe Schwalm, Miriam Hamzehpour, Lara Stroh, Albrecht eLife Neuroscience Previously, using simultaneous resting-state functional magnetic resonance imaging (fMRI) and photometry-based neuronal calcium recordings in the anesthetized rat, we identified blood oxygenation level-dependent (BOLD) responses directly related to slow calcium waves, revealing a cortex-wide and spatially organized correlate of locally recorded neuronal activity (Schwalm et al., 2017). Here, using the same techniques, we investigate two distinct cortical activity states: persistent activity, in which compartmentalized network dynamics were observed; and slow wave activity, dominated by a cortex-wide BOLD component, suggesting a strong functional coupling of inter-cortical activity. During slow wave activity, we find a correlation between the occurring slow wave events and the strength of functional connectivity between different cortical areas. These findings suggest that down-up transitions of neuronal excitability can drive cortex-wide functional connectivity. This study provides further evidence that changes in functional connectivity are dependent on the brain’s current state, directly linked to the generation of slow waves. eLife Sciences Publications, Ltd 2020-06-22 /pmc/articles/PMC7329332/ /pubmed/32568067 http://dx.doi.org/10.7554/eLife.53186 Text en © 2020, Aedo-Jury et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Aedo-Jury, Felipe Schwalm, Miriam Hamzehpour, Lara Stroh, Albrecht Brain states govern the spatio-temporal dynamics of resting-state functional connectivity |
title | Brain states govern the spatio-temporal dynamics of resting-state functional connectivity |
title_full | Brain states govern the spatio-temporal dynamics of resting-state functional connectivity |
title_fullStr | Brain states govern the spatio-temporal dynamics of resting-state functional connectivity |
title_full_unstemmed | Brain states govern the spatio-temporal dynamics of resting-state functional connectivity |
title_short | Brain states govern the spatio-temporal dynamics of resting-state functional connectivity |
title_sort | brain states govern the spatio-temporal dynamics of resting-state functional connectivity |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329332/ https://www.ncbi.nlm.nih.gov/pubmed/32568067 http://dx.doi.org/10.7554/eLife.53186 |
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