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Inhibitors in AKTion: ATP-competitive vs allosteric

Aberrant activation of the PI3K pathway is one of the commonest oncogenic events in human cancer. AKT is a key mediator of PI3K oncogenic function, and thus has been intensely pursued as a therapeutic target. Multiple AKT inhibitors, broadly classified as either ATP-competitive or allosteric, are cu...

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Detalles Bibliográficos
Autores principales:	Lazaro, Glorianne, Kostaras, Eleftherios, Vivanco, Igor
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2020
Materias:	Review Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329346/ https://www.ncbi.nlm.nih.gov/pubmed/32453400 http://dx.doi.org/10.1042/BST20190777

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