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Retrospective study 2005–2015 of all cases of fetal death occurred at ≥23 gestational weeks, in Friuli Venezia Giulia, Italy

BACKGROUND: Intrauterine fetal death (IUFD) is a tragic event and, despite efforts to reduce rates, its incidence remains difficult to reduce. The objective of the present study was to examine the etiological factors that contribute to the main causes and conditions associated with IUFD, over an 11-...

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Autores principales: Monasta, Lorenzo, Giangreco, Manuela, Ancona, Emanuele, Barbone, Fabio, Bet, Elisa, Boschian-Bailo, Pierino, Cacciaguerra, Giovanna, Cagnacci, Angelo, Canton, Melania, Casarotto, Maddalena, Comar, Manola, Contardo, Simona, De Agostini, Michela, De Seta, Francesco, Del Ben, Giovanni, Di Loreto, Carla, Driul, Lorenza, Facchin, Stefano, Giornelli, Roberta, Ianni, Annalisa, La Valle, Santo, Londero, Ambrogio Pietro, Manfè, Marciano, Maso, Gianpaolo, Mugittu, Raffaela, Olivuzzi, Monica, Orsaria, Maria, Pecile, Vanna, Pinzano, Roberta, Pirrone, Francesco, Quadrifoglio, Mariachiara, Ricci, Giuseppe, Ronfani, Luca, Salviato, Tiziana, Sandrigo, Elisa, Smiroldo, Silvia, Sorz, Alice, Stampalija, Tamara, Urriza, Marianela, Vanin, Michele, Verardi, Giuseppina, Alberico, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329413/
https://www.ncbi.nlm.nih.gov/pubmed/32611322
http://dx.doi.org/10.1186/s12884-020-03074-9
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author Monasta, Lorenzo
Giangreco, Manuela
Ancona, Emanuele
Barbone, Fabio
Bet, Elisa
Boschian-Bailo, Pierino
Cacciaguerra, Giovanna
Cagnacci, Angelo
Canton, Melania
Casarotto, Maddalena
Comar, Manola
Contardo, Simona
De Agostini, Michela
De Seta, Francesco
Del Ben, Giovanni
Di Loreto, Carla
Driul, Lorenza
Facchin, Stefano
Giornelli, Roberta
Ianni, Annalisa
La Valle, Santo
Londero, Ambrogio Pietro
Manfè, Marciano
Maso, Gianpaolo
Mugittu, Raffaela
Olivuzzi, Monica
Orsaria, Maria
Pecile, Vanna
Pinzano, Roberta
Pirrone, Francesco
Quadrifoglio, Mariachiara
Ricci, Giuseppe
Ronfani, Luca
Salviato, Tiziana
Sandrigo, Elisa
Smiroldo, Silvia
Sorz, Alice
Stampalija, Tamara
Urriza, Marianela
Vanin, Michele
Verardi, Giuseppina
Alberico, Salvatore
author_facet Monasta, Lorenzo
Giangreco, Manuela
Ancona, Emanuele
Barbone, Fabio
Bet, Elisa
Boschian-Bailo, Pierino
Cacciaguerra, Giovanna
Cagnacci, Angelo
Canton, Melania
Casarotto, Maddalena
Comar, Manola
Contardo, Simona
De Agostini, Michela
De Seta, Francesco
Del Ben, Giovanni
Di Loreto, Carla
Driul, Lorenza
Facchin, Stefano
Giornelli, Roberta
Ianni, Annalisa
La Valle, Santo
Londero, Ambrogio Pietro
Manfè, Marciano
Maso, Gianpaolo
Mugittu, Raffaela
Olivuzzi, Monica
Orsaria, Maria
Pecile, Vanna
Pinzano, Roberta
Pirrone, Francesco
Quadrifoglio, Mariachiara
Ricci, Giuseppe
Ronfani, Luca
Salviato, Tiziana
Sandrigo, Elisa
Smiroldo, Silvia
Sorz, Alice
Stampalija, Tamara
Urriza, Marianela
Vanin, Michele
Verardi, Giuseppina
Alberico, Salvatore
author_sort Monasta, Lorenzo
collection PubMed
description BACKGROUND: Intrauterine fetal death (IUFD) is a tragic event and, despite efforts to reduce rates, its incidence remains difficult to reduce. The objective of the present study was to examine the etiological factors that contribute to the main causes and conditions associated with IUFD, over an 11-year period in a region of North-East Italy (Friuli Venezia Giulia) for which reliable data in available. METHODS: Retrospective analysis of all 278 IUFD cases occurred between 2005 and 2015 in pregnancies with gestational age ≥ 23 weeks. RESULTS: The incidence of IUFD was 2.8‰ live births. Of these, 30% were small for gestational age (SGA), with immigrant women being significantly over-represented. The share of SGA reached 35% in cases in which a maternal of fetal pathological condition was present, and dropped to 28% in the absence of associated pathology. In 78 pregnancies (28%) no pathology was recorded that could justify IUFD. Of all IUFDs, 11% occurred during labor, and 72% occurred at a gestational age above 30 weeks. CONCLUSION: The percentage of IUFD cases for which no possible cause can be identified is quite high. Only the adoption of evidence-based diagnostic protocols, with integrated immunologic, genetic and pathologic examinations, can help reduce this diagnostic gap, contributing to the prevention of future IUFDs.
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spelling pubmed-73294132020-07-02 Retrospective study 2005–2015 of all cases of fetal death occurred at ≥23 gestational weeks, in Friuli Venezia Giulia, Italy Monasta, Lorenzo Giangreco, Manuela Ancona, Emanuele Barbone, Fabio Bet, Elisa Boschian-Bailo, Pierino Cacciaguerra, Giovanna Cagnacci, Angelo Canton, Melania Casarotto, Maddalena Comar, Manola Contardo, Simona De Agostini, Michela De Seta, Francesco Del Ben, Giovanni Di Loreto, Carla Driul, Lorenza Facchin, Stefano Giornelli, Roberta Ianni, Annalisa La Valle, Santo Londero, Ambrogio Pietro Manfè, Marciano Maso, Gianpaolo Mugittu, Raffaela Olivuzzi, Monica Orsaria, Maria Pecile, Vanna Pinzano, Roberta Pirrone, Francesco Quadrifoglio, Mariachiara Ricci, Giuseppe Ronfani, Luca Salviato, Tiziana Sandrigo, Elisa Smiroldo, Silvia Sorz, Alice Stampalija, Tamara Urriza, Marianela Vanin, Michele Verardi, Giuseppina Alberico, Salvatore BMC Pregnancy Childbirth Research Article BACKGROUND: Intrauterine fetal death (IUFD) is a tragic event and, despite efforts to reduce rates, its incidence remains difficult to reduce. The objective of the present study was to examine the etiological factors that contribute to the main causes and conditions associated with IUFD, over an 11-year period in a region of North-East Italy (Friuli Venezia Giulia) for which reliable data in available. METHODS: Retrospective analysis of all 278 IUFD cases occurred between 2005 and 2015 in pregnancies with gestational age ≥ 23 weeks. RESULTS: The incidence of IUFD was 2.8‰ live births. Of these, 30% were small for gestational age (SGA), with immigrant women being significantly over-represented. The share of SGA reached 35% in cases in which a maternal of fetal pathological condition was present, and dropped to 28% in the absence of associated pathology. In 78 pregnancies (28%) no pathology was recorded that could justify IUFD. Of all IUFDs, 11% occurred during labor, and 72% occurred at a gestational age above 30 weeks. CONCLUSION: The percentage of IUFD cases for which no possible cause can be identified is quite high. Only the adoption of evidence-based diagnostic protocols, with integrated immunologic, genetic and pathologic examinations, can help reduce this diagnostic gap, contributing to the prevention of future IUFDs. BioMed Central 2020-07-01 /pmc/articles/PMC7329413/ /pubmed/32611322 http://dx.doi.org/10.1186/s12884-020-03074-9 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Monasta, Lorenzo
Giangreco, Manuela
Ancona, Emanuele
Barbone, Fabio
Bet, Elisa
Boschian-Bailo, Pierino
Cacciaguerra, Giovanna
Cagnacci, Angelo
Canton, Melania
Casarotto, Maddalena
Comar, Manola
Contardo, Simona
De Agostini, Michela
De Seta, Francesco
Del Ben, Giovanni
Di Loreto, Carla
Driul, Lorenza
Facchin, Stefano
Giornelli, Roberta
Ianni, Annalisa
La Valle, Santo
Londero, Ambrogio Pietro
Manfè, Marciano
Maso, Gianpaolo
Mugittu, Raffaela
Olivuzzi, Monica
Orsaria, Maria
Pecile, Vanna
Pinzano, Roberta
Pirrone, Francesco
Quadrifoglio, Mariachiara
Ricci, Giuseppe
Ronfani, Luca
Salviato, Tiziana
Sandrigo, Elisa
Smiroldo, Silvia
Sorz, Alice
Stampalija, Tamara
Urriza, Marianela
Vanin, Michele
Verardi, Giuseppina
Alberico, Salvatore
Retrospective study 2005–2015 of all cases of fetal death occurred at ≥23 gestational weeks, in Friuli Venezia Giulia, Italy
title Retrospective study 2005–2015 of all cases of fetal death occurred at ≥23 gestational weeks, in Friuli Venezia Giulia, Italy
title_full Retrospective study 2005–2015 of all cases of fetal death occurred at ≥23 gestational weeks, in Friuli Venezia Giulia, Italy
title_fullStr Retrospective study 2005–2015 of all cases of fetal death occurred at ≥23 gestational weeks, in Friuli Venezia Giulia, Italy
title_full_unstemmed Retrospective study 2005–2015 of all cases of fetal death occurred at ≥23 gestational weeks, in Friuli Venezia Giulia, Italy
title_short Retrospective study 2005–2015 of all cases of fetal death occurred at ≥23 gestational weeks, in Friuli Venezia Giulia, Italy
title_sort retrospective study 2005–2015 of all cases of fetal death occurred at ≥23 gestational weeks, in friuli venezia giulia, italy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329413/
https://www.ncbi.nlm.nih.gov/pubmed/32611322
http://dx.doi.org/10.1186/s12884-020-03074-9
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