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The establishment of a rheumatoid arthritis primate model in Macaca fascicularis

BACKGROUND: Rheumatoid arthritis (RA) is a long-term autoimmune disorder that mostly affects the joints and leads to the destruction of cartilage. An RA model in non-human primates is especially useful because of their close phylogenetic relationship to humans in terms of cross-reactivity to compoun...

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Autores principales: Na, Hyun Sik, Lee, Seon-yeong, Min, Hong Ki, Park, Wan-je, Lee, Jung-hwan, Cho, Ka-hee, Hong, Shin-hee, Kim, Dae-hoon, Jhun, Jooyeon, Choi, Jeong-Won, Kim, Sung-Min, Kwok, Seung-Ki, Cho, Mi-La, Park, Sung-Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329448/
https://www.ncbi.nlm.nih.gov/pubmed/32605610
http://dx.doi.org/10.1186/s12967-020-02402-z
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author Na, Hyun Sik
Lee, Seon-yeong
Min, Hong Ki
Park, Wan-je
Lee, Jung-hwan
Cho, Ka-hee
Hong, Shin-hee
Kim, Dae-hoon
Jhun, Jooyeon
Choi, Jeong-Won
Kim, Sung-Min
Kwok, Seung-Ki
Cho, Mi-La
Park, Sung-Hwan
author_facet Na, Hyun Sik
Lee, Seon-yeong
Min, Hong Ki
Park, Wan-je
Lee, Jung-hwan
Cho, Ka-hee
Hong, Shin-hee
Kim, Dae-hoon
Jhun, Jooyeon
Choi, Jeong-Won
Kim, Sung-Min
Kwok, Seung-Ki
Cho, Mi-La
Park, Sung-Hwan
author_sort Na, Hyun Sik
collection PubMed
description BACKGROUND: Rheumatoid arthritis (RA) is a long-term autoimmune disorder that mostly affects the joints and leads to the destruction of cartilage. An RA model in non-human primates is especially useful because of their close phylogenetic relationship to humans in terms of cross-reactivity to compounds developed using modern drug technologies. METHODS: We used a collagen-induced arthritis (CIA) model in Macaca fascicularis. CIA was induced by the immunization of chicken type II collagen. Swelling was measured as the longitudinal and transverse axes of 16 proximal interphalangeal joints. RESULTS: A new system for visual evaluation was created, with a perfect score of 16. Individual behavioral analysis was also conducted. Serum was collected once a week after the first immunization. Blood chemistry and inflammatory cytokine parameters were higher in the CIA group than in the wild type group. CONCLUSION: In conclusion, we established CIA in M. fascicularis, and the results can be used for drug evaluation models.
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spelling pubmed-73294482020-07-02 The establishment of a rheumatoid arthritis primate model in Macaca fascicularis Na, Hyun Sik Lee, Seon-yeong Min, Hong Ki Park, Wan-je Lee, Jung-hwan Cho, Ka-hee Hong, Shin-hee Kim, Dae-hoon Jhun, Jooyeon Choi, Jeong-Won Kim, Sung-Min Kwok, Seung-Ki Cho, Mi-La Park, Sung-Hwan J Transl Med Research BACKGROUND: Rheumatoid arthritis (RA) is a long-term autoimmune disorder that mostly affects the joints and leads to the destruction of cartilage. An RA model in non-human primates is especially useful because of their close phylogenetic relationship to humans in terms of cross-reactivity to compounds developed using modern drug technologies. METHODS: We used a collagen-induced arthritis (CIA) model in Macaca fascicularis. CIA was induced by the immunization of chicken type II collagen. Swelling was measured as the longitudinal and transverse axes of 16 proximal interphalangeal joints. RESULTS: A new system for visual evaluation was created, with a perfect score of 16. Individual behavioral analysis was also conducted. Serum was collected once a week after the first immunization. Blood chemistry and inflammatory cytokine parameters were higher in the CIA group than in the wild type group. CONCLUSION: In conclusion, we established CIA in M. fascicularis, and the results can be used for drug evaluation models. BioMed Central 2020-06-30 /pmc/articles/PMC7329448/ /pubmed/32605610 http://dx.doi.org/10.1186/s12967-020-02402-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Na, Hyun Sik
Lee, Seon-yeong
Min, Hong Ki
Park, Wan-je
Lee, Jung-hwan
Cho, Ka-hee
Hong, Shin-hee
Kim, Dae-hoon
Jhun, Jooyeon
Choi, Jeong-Won
Kim, Sung-Min
Kwok, Seung-Ki
Cho, Mi-La
Park, Sung-Hwan
The establishment of a rheumatoid arthritis primate model in Macaca fascicularis
title The establishment of a rheumatoid arthritis primate model in Macaca fascicularis
title_full The establishment of a rheumatoid arthritis primate model in Macaca fascicularis
title_fullStr The establishment of a rheumatoid arthritis primate model in Macaca fascicularis
title_full_unstemmed The establishment of a rheumatoid arthritis primate model in Macaca fascicularis
title_short The establishment of a rheumatoid arthritis primate model in Macaca fascicularis
title_sort establishment of a rheumatoid arthritis primate model in macaca fascicularis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329448/
https://www.ncbi.nlm.nih.gov/pubmed/32605610
http://dx.doi.org/10.1186/s12967-020-02402-z
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