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Treatment outcomes of patients with tuberculosis in war affected region of Khyber Pakhtunkhwa, Pakistan
BACKGROUND: Globally, tuberculosis (TB) remains the leading cause of death from a single infectious disease. TB treatment outcome is an important indicator for the effectiveness of a national TB control program. This study aimed to assess treatment outcomes of TB patients and its determinants in Bat...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329461/ https://www.ncbi.nlm.nih.gov/pubmed/32611409 http://dx.doi.org/10.1186/s12879-020-05184-3 |
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author | Ahmad, Tauseef Jadoon, Muhammad Ayub Khan, Muhammad Haroon Khan, Muhammad Mumtaz Hussain, Akbar Musa, Taha Hussein Waqar, Muhammad Ejeta, Eyasu Karami, Manoochehr Alene, Kefyalew Addis Jin, Hui |
author_facet | Ahmad, Tauseef Jadoon, Muhammad Ayub Khan, Muhammad Haroon Khan, Muhammad Mumtaz Hussain, Akbar Musa, Taha Hussein Waqar, Muhammad Ejeta, Eyasu Karami, Manoochehr Alene, Kefyalew Addis Jin, Hui |
author_sort | Ahmad, Tauseef |
collection | PubMed |
description | BACKGROUND: Globally, tuberculosis (TB) remains the leading cause of death from a single infectious disease. TB treatment outcome is an important indicator for the effectiveness of a national TB control program. This study aimed to assess treatment outcomes of TB patients and its determinants in Batkhela, Khyber Pakhtunkhwa, Pakistan. METHODS: A retrospective cohort study was designed using all TB patients who were enrolled at District Head Quarter (DHQ) Hospital Batkhela, Pakistan, from January 2011 to December 2014. A binary logistic regression models were used to identify factors associated with successful TB treatment outcomes defined as the sum of cure and completed treatment. RESULTS: A total of 515 TB patients were registered, of which 237 (46%) were males and 278 (53.98%) females. Of all patients, 234 (45.44%) were cured and 210 (40.77%) completed treatment. The overall treatment success rate was 444 (86.21%). Age 0–20 years (adjusted odds ratio, AOR = 3.47; 95% confidence interval, CI) = 1.54–7.81; P = 0.003), smear-positive pulmonary TB (AOR) = 3.58; 95% CI = 1.89–6.78; P = < 0.001), treatment category (AOR = 4.71; 95% CI = 1.17–18.97; P = 0.029), and year of enrollment 2012 (AOR = 6.26; 95% CI = 2.52–15.59; P = < 0.001) were significantly associated with successful treatment outcome. CONCLUSIONS: The overall treatment success rate is satisfactory but still need to be improved to achieve the international targeted treatment outcome. Type of TB, age, treatment category, and year of enrollment were significantly associated with successful treatment outcomes. |
format | Online Article Text |
id | pubmed-7329461 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-73294612020-07-02 Treatment outcomes of patients with tuberculosis in war affected region of Khyber Pakhtunkhwa, Pakistan Ahmad, Tauseef Jadoon, Muhammad Ayub Khan, Muhammad Haroon Khan, Muhammad Mumtaz Hussain, Akbar Musa, Taha Hussein Waqar, Muhammad Ejeta, Eyasu Karami, Manoochehr Alene, Kefyalew Addis Jin, Hui BMC Infect Dis Research Article BACKGROUND: Globally, tuberculosis (TB) remains the leading cause of death from a single infectious disease. TB treatment outcome is an important indicator for the effectiveness of a national TB control program. This study aimed to assess treatment outcomes of TB patients and its determinants in Batkhela, Khyber Pakhtunkhwa, Pakistan. METHODS: A retrospective cohort study was designed using all TB patients who were enrolled at District Head Quarter (DHQ) Hospital Batkhela, Pakistan, from January 2011 to December 2014. A binary logistic regression models were used to identify factors associated with successful TB treatment outcomes defined as the sum of cure and completed treatment. RESULTS: A total of 515 TB patients were registered, of which 237 (46%) were males and 278 (53.98%) females. Of all patients, 234 (45.44%) were cured and 210 (40.77%) completed treatment. The overall treatment success rate was 444 (86.21%). Age 0–20 years (adjusted odds ratio, AOR = 3.47; 95% confidence interval, CI) = 1.54–7.81; P = 0.003), smear-positive pulmonary TB (AOR) = 3.58; 95% CI = 1.89–6.78; P = < 0.001), treatment category (AOR = 4.71; 95% CI = 1.17–18.97; P = 0.029), and year of enrollment 2012 (AOR = 6.26; 95% CI = 2.52–15.59; P = < 0.001) were significantly associated with successful treatment outcome. CONCLUSIONS: The overall treatment success rate is satisfactory but still need to be improved to achieve the international targeted treatment outcome. Type of TB, age, treatment category, and year of enrollment were significantly associated with successful treatment outcomes. BioMed Central 2020-07-01 /pmc/articles/PMC7329461/ /pubmed/32611409 http://dx.doi.org/10.1186/s12879-020-05184-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Ahmad, Tauseef Jadoon, Muhammad Ayub Khan, Muhammad Haroon Khan, Muhammad Mumtaz Hussain, Akbar Musa, Taha Hussein Waqar, Muhammad Ejeta, Eyasu Karami, Manoochehr Alene, Kefyalew Addis Jin, Hui Treatment outcomes of patients with tuberculosis in war affected region of Khyber Pakhtunkhwa, Pakistan |
title | Treatment outcomes of patients with tuberculosis in war affected region of Khyber Pakhtunkhwa, Pakistan |
title_full | Treatment outcomes of patients with tuberculosis in war affected region of Khyber Pakhtunkhwa, Pakistan |
title_fullStr | Treatment outcomes of patients with tuberculosis in war affected region of Khyber Pakhtunkhwa, Pakistan |
title_full_unstemmed | Treatment outcomes of patients with tuberculosis in war affected region of Khyber Pakhtunkhwa, Pakistan |
title_short | Treatment outcomes of patients with tuberculosis in war affected region of Khyber Pakhtunkhwa, Pakistan |
title_sort | treatment outcomes of patients with tuberculosis in war affected region of khyber pakhtunkhwa, pakistan |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329461/ https://www.ncbi.nlm.nih.gov/pubmed/32611409 http://dx.doi.org/10.1186/s12879-020-05184-3 |
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