Analysis of endothelial-to-haematopoietic transition at the single cell level identifies cell cycle regulation as a driver of differentiation

BACKGROUND: Haematopoietic stem cells (HSCs) first arise during development in the aorta-gonad-mesonephros (AGM) region of the embryo from a population of haemogenic endothelial cells which undergo endothelial-to-haematopoietic transition (EHT). Despite the progress achieved in recent years, the mol...

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Detalles Bibliográficos
Autores principales: Canu, Giovanni, Athanasiadis, Emmanouil, Grandy, Rodrigo A., Garcia-Bernardo, Jose, Strzelecka, Paulina M., Vallier, Ludovic, Ortmann, Daniel, Cvejic, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329542/
https://www.ncbi.nlm.nih.gov/pubmed/32611441
http://dx.doi.org/10.1186/s13059-020-02058-4

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