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Ameliorative effect of Argyreia boseana Sant. & Pat. on stress in C. elegans
BACKGROUND: Argyreia boseana Santapau and Patel commonly known as Kumbharao belongs to the family of Convolvulaceae. The plant is rare in distribution and found chiefly in the dediapada region of Gujarat. Traditionally it is used by the tribals of south Gujarat forest region in the treatment of vari...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329712/ https://www.ncbi.nlm.nih.gov/pubmed/30448258 http://dx.doi.org/10.1016/j.jaim.2017.11.001 |
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author | Doshi, Shital Braganza, Vincent |
author_facet | Doshi, Shital Braganza, Vincent |
author_sort | Doshi, Shital |
collection | PubMed |
description | BACKGROUND: Argyreia boseana Santapau and Patel commonly known as Kumbharao belongs to the family of Convolvulaceae. The plant is rare in distribution and found chiefly in the dediapada region of Gujarat. Traditionally it is used by the tribals of south Gujarat forest region in the treatment of various diseases of the nervous system. In order to study the scientific basis of the plants effect we set out to investigate the effect of the plant on ageing organisms and used Caenorhabditis elegans as a model. OBJECTIVE: To evaluate the effect of crude extract of leaves, prepared from A. boseana on oxidative stress, thermal stress, longevity and in vivo gene expression of C. elegans. MATERIAL AND METHODS: Plant extracts was prepared by sonication based method using solvent ethanol:water. Longevity experiments were carried out in liquid S media. Oxidative stress was induced by paraquat. RESULT: Results indicate no increase in the normal life span of C. elegans. However, A. boseana significantly induces stress tolerance and increased the mean lifespan of worms during thermal and oxidative stress. Additionally A. boseana was also able to up regulate the stress associated gene gst-4. CONCLUSION: Thus the present study, for the first time, unravels the anti-stress and ROS modulating effect of A. boseana. |
format | Online Article Text |
id | pubmed-7329712 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-73297122020-07-06 Ameliorative effect of Argyreia boseana Sant. & Pat. on stress in C. elegans Doshi, Shital Braganza, Vincent J Ayurveda Integr Med Original Research Article- Experimental BACKGROUND: Argyreia boseana Santapau and Patel commonly known as Kumbharao belongs to the family of Convolvulaceae. The plant is rare in distribution and found chiefly in the dediapada region of Gujarat. Traditionally it is used by the tribals of south Gujarat forest region in the treatment of various diseases of the nervous system. In order to study the scientific basis of the plants effect we set out to investigate the effect of the plant on ageing organisms and used Caenorhabditis elegans as a model. OBJECTIVE: To evaluate the effect of crude extract of leaves, prepared from A. boseana on oxidative stress, thermal stress, longevity and in vivo gene expression of C. elegans. MATERIAL AND METHODS: Plant extracts was prepared by sonication based method using solvent ethanol:water. Longevity experiments were carried out in liquid S media. Oxidative stress was induced by paraquat. RESULT: Results indicate no increase in the normal life span of C. elegans. However, A. boseana significantly induces stress tolerance and increased the mean lifespan of worms during thermal and oxidative stress. Additionally A. boseana was also able to up regulate the stress associated gene gst-4. CONCLUSION: Thus the present study, for the first time, unravels the anti-stress and ROS modulating effect of A. boseana. Elsevier 2020 2018-11-15 /pmc/articles/PMC7329712/ /pubmed/30448258 http://dx.doi.org/10.1016/j.jaim.2017.11.001 Text en © 2018 Transdisciplinary University, Bangalore and World Ayurveda Foundation. Publishing Services by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Research Article- Experimental Doshi, Shital Braganza, Vincent Ameliorative effect of Argyreia boseana Sant. & Pat. on stress in C. elegans |
title | Ameliorative effect of Argyreia boseana Sant. & Pat. on stress in C. elegans |
title_full | Ameliorative effect of Argyreia boseana Sant. & Pat. on stress in C. elegans |
title_fullStr | Ameliorative effect of Argyreia boseana Sant. & Pat. on stress in C. elegans |
title_full_unstemmed | Ameliorative effect of Argyreia boseana Sant. & Pat. on stress in C. elegans |
title_short | Ameliorative effect of Argyreia boseana Sant. & Pat. on stress in C. elegans |
title_sort | ameliorative effect of argyreia boseana sant. & pat. on stress in c. elegans |
topic | Original Research Article- Experimental |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329712/ https://www.ncbi.nlm.nih.gov/pubmed/30448258 http://dx.doi.org/10.1016/j.jaim.2017.11.001 |
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