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Conservation and divergence in NaChBac and Na(V)1.7 pharmacology reveals novel drug interaction mechanisms

Voltage-gated Na(+) (Na(V)) channels regulate homeostasis in bacteria and control membrane electrical excitability in mammals. Compared to their mammalian counterparts, bacterial Na(V) channels possess a simpler, fourfold symmetric structure and have facilitated studies of the structural basis of ch...

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Detalles Bibliográficos
Autores principales:	Zhu, Wandi, Li, Tianbo, Silva, Jonathan R., Chen, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329812/ https://www.ncbi.nlm.nih.gov/pubmed/32612253 http://dx.doi.org/10.1038/s41598-020-67761-5

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