Cargando…

A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction

Osteocytes, cells ensconced within mineralized bone matrix, are the primary skeletal mechanosensors. Osteocytes sense mechanical cues by changes in fluid flow shear stress (FFSS) across their dendritic projections. Loading-induced reductions of osteocytic Sclerostin (encoded by Sost) expression stim...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sato, Tadatoshi, Verma, Shiv, Andrade, Christian D. Castro, Omeara, Maureen, Campbell, Nia, Wang, Jialiang S., Cetinbas, Murat, Lang, Audrey, Ausk, Brandon J., Brooks, Daniel J., Sadreyev, Ruslan I., Kronenberg, Henry M., Lagares, David, Uda, Yuhei, Pajevic, Paola Divieti, Bouxsein, Mary L., Gross, Ted S., Wein, Marc N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329900/ https://www.ncbi.nlm.nih.gov/pubmed/32612176 http://dx.doi.org/10.1038/s41467-020-17099-3

Ejemplares similares

PTH Protects Osteocytes From Oxidative Stress and Cellular Senescence
por: Uda, Yuhei, et al.
Publicado: (2021)

Recent Progress in Osteocyte Research
por: Divieti Pajevic, Paola
Publicado: (2013)

SIKs control osteocyte responses to parathyroid hormone
por: Wein, Marc N., et al.
Publicado: (2016)

Corrigendum: SIKs control osteocyte responses to parathyroid hormone
por: Wein, Marc N., et al.
Publicado: (2017)

Osteocyte secreted factors inhibit skeletal muscle differentiation
por: Wood, Charles L., et al.
Publicado: (2017)

Aging, Osteocytes, and Mechanotransduction
por: Hemmatian, Haniyeh, et al.
Publicado: (2017)

Partial prevention of glucocorticoid-induced osteocyte deterioration in young male mice with osteocrin gene therapy
por: Mazur, Courtney M., et al.
Publicado: (2022)

MON-LB087 Synthesis of Osteocyte-Derived Phosphaturic Hormone FGF23 via IP3/PKC Signaling Downstream of the Extra-Large Gα Subunit (XLαs)
por: He, Qing, et al.
Publicado: (2019)

FAK-Mediated Mechanotransduction in Skeletal Regeneration
por: Leucht, Philipp, et al.
Publicado: (2007)

Parathyroid hormone signaling in mature osteoblasts/osteocytes protects mice from age-related bone loss
por: Uda, Yuhei, et al.
Publicado: (2021)

Pathways Controlling Formation and Maintenance of the Osteocyte Dendrite Network
por: Wang, Jialiang S., et al.
Publicado: (2022)

Amphiregulin-EGFR Signaling Mediates the Migration of Bone Marrow Mesenchymal Progenitors toward PTH-Stimulated Osteoblasts and Osteocytes
por: Zhu, Ji, et al.
Publicado: (2012)

Increased sphingosine-1-phosphate production in response to osteocyte mechanotransduction
por: Dobrosak, Cale, et al.
Publicado: (2017)

Involvement of the FAK Network in Pathologies Related to Altered Mechanotransduction
por: Urciuoli, Enrica, et al.
Publicado: (2020)

The potential role of spectrin network in the mechanotransduction of MLO-Y4 osteocytes
por: Wu, Xin-Tong, et al.
Publicado: (2017)

Kindlin-2 mediates mechanotransduction in bone by regulating expression of Sclerostin in osteocytes
por: Qin, Lei, et al.
Publicado: (2021)

The role of osteocytes-specific molecular mechanism in regulation of mechanotransduction – A systematic review
por: Li, Meng Chen Michelle, et al.
Publicado: (2021)

Parathyroid Hormone Signaling in Osteocytes
por: Wein, Marc N
Publicado: (2017)

Subcellular domain-dependent molecular hierarchy of SFK and FAK in mechanotransduction and cytokine signaling
por: Wan, Qiaoqiao, et al.
Publicado: (2017)

Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin
por: Wang, Jialiang S., et al.
Publicado: (2021)

Microenvironmental stiffness mediates cytoskeleton re-organization in chondrocytes through laminin-FAK mechanotransduction
por: Zhou, Chenchen, et al.
Publicado: (2022)

Osteocyte β1 integrin loss causes low bone mass and impairs bone mechanotransduction in mice
por: Qin, Lei, et al.
Publicado: (2022)

Systems-Based Identification of Temporal Processing Pathways during Bone Cell Mechanotransduction
por: Worton, Leah E., et al.
Publicado: (2013)

Non-Overlapping Functions for Pyk2 and FAK in Osteoblasts during Fluid Shear Stress-Induced Mechanotransduction
por: Young, Suzanne R. L., et al.
Publicado: (2011)

Genome-wide analysis identifies cis-acting elements regulating mRNA polyadenylation and translation during vertebrate oocyte maturation
por: Yang, Fei, et al.
Publicado: (2020)

Long-term dysbiosis and fluctuations of gut microbiome in antibiotic treated preterm infants
por: Cetinbas, Murat, et al.
Publicado: (2023)

Distinct functions of tissue-resident and circulating memory Th2 cells in allergic airway disease
por: Rahimi, Rod A., et al.
Publicado: (2020)

Intravital imaging of osteocytes in mouse calvaria using third harmonic generation microscopy
por: Tokarz, Danielle, et al.
Publicado: (2017)

Impaired Gastric Hormone Regulation of Osteoblasts and Lysyl Oxidase Drives Bone Disease in Diabetes Mellitus
por: Daley, Eileen J, et al.
Publicado: (2019)

Impaired 1,25 dihydroxyvitamin D(3) action and hypophosphatemia underlie the altered lacuno-canalicular remodeling observed in the Hyp mouse model of XLH
por: Yuan, Ye, et al.
Publicado: (2021)

Control of Bone Mass and Remodeling by PTH Receptor Signaling in Osteocytes
por: O'Brien, Charles A., et al.
Publicado: (2008)

The Amazing Osteocyte
por: Bonewald, Lynda F
Publicado: (2011)

Osteocytes and Weightlessness
por: Iandolo, Donata, et al.
Publicado: (2021)

Mechanotransduction in osteogenesis
por: Stewart, Sarah, et al.
Publicado: (2020)

Extracellular mechanotransduction
por: Haller, Stephen J., et al.
Publicado: (2022)

Comparative study in estrogen-depleted mice identifies skeletal and osteocyte transcriptomic responses to abaloparatide and teriparatide
por: Lv, Zhengtao, et al.
Publicado: (2023)

Human gut derived-organoids provide model to study gluten response and effects of microbiota-derived molecules in celiac disease
por: Freire, Rachel, et al.
Publicado: (2019)

Loss of muscleblind splicing factor shortens Caenorhabditis elegans lifespan by reducing the activity of p38 MAPK/PMK-1 and transcription factors ATF-7 and Nrf/SKN-1
por: Matilainen, Olli, et al.
Publicado: (2021)

Heparan Sulfate Proteoglycans Mediate Interstitial Flow Mechanotransduction Regulating MMP-13 Expression and Cell Motility via FAK-ERK in 3D Collagen
por: Shi, Zhong-Dong, et al.
Publicado: (2011)

Exploiting the Zonulin Mouse Model to Establish the Role of Primary Impaired Gut Barrier Function on Microbiota Composition and Immune Profiles
por: Miranda-Ribera, Alba, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_okmpgqv70fj2bitfjfpck5474r