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The biological age of the heart is consistently younger than chronological age
Chronological age represents the main factor in donor selection criteria for organ transplantation, however aging is very heterogeneous. Defining the biological aging of individual organs may contribute to supporting this process. In this study we examined the biological age of the heart [right (RA)...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329913/ https://www.ncbi.nlm.nih.gov/pubmed/32612244 http://dx.doi.org/10.1038/s41598-020-67622-1 |
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author | Pavanello, Sofia Campisi, Manuela Fabozzo, Assunta Cibin, Giorgia Tarzia, Vincenzo Toscano, Giuseppe Gerosa, Gino |
author_facet | Pavanello, Sofia Campisi, Manuela Fabozzo, Assunta Cibin, Giorgia Tarzia, Vincenzo Toscano, Giuseppe Gerosa, Gino |
author_sort | Pavanello, Sofia |
collection | PubMed |
description | Chronological age represents the main factor in donor selection criteria for organ transplantation, however aging is very heterogeneous. Defining the biological aging of individual organs may contribute to supporting this process. In this study we examined the biological age of the heart [right (RA)/left atrium (LA)] and peripheral blood leucocytes in the same subject, and compared these to assess whether blood mirrors cardiac biological aging. Biological aging was studied in 35 donors (0.4–72 years) by exploring mitotic and non-mitotic pathways, using telomere length (TL) and age-dependent methylation changes in certain CpG loci (DNAmAge). Heart non-mitotic DNAmAge was strongly younger than that of both blood (− 10 years, p < 0.0001) and chronological age (− 12 years, p < 0.0001). Instead, heart and blood mitotic age (TL) were similar, and there was no difference in DNAmAge and TL between RA and LA. DNAmAge negatively correlated with TL in heart and blood (p ≤ 0.01). Finally, blood and heart TL (p < 0.01) and DNAmAge (p < 0.0001) were correlated. Therefore, blood can be a proxy indicator of heart biological age. While future investigation on post-transplant graft performance in relation to biological aging is still needed, our study could contribute to opening up novel basic and clinical research platforms in the field of organ transplantation. |
format | Online Article Text |
id | pubmed-7329913 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-73299132020-07-06 The biological age of the heart is consistently younger than chronological age Pavanello, Sofia Campisi, Manuela Fabozzo, Assunta Cibin, Giorgia Tarzia, Vincenzo Toscano, Giuseppe Gerosa, Gino Sci Rep Article Chronological age represents the main factor in donor selection criteria for organ transplantation, however aging is very heterogeneous. Defining the biological aging of individual organs may contribute to supporting this process. In this study we examined the biological age of the heart [right (RA)/left atrium (LA)] and peripheral blood leucocytes in the same subject, and compared these to assess whether blood mirrors cardiac biological aging. Biological aging was studied in 35 donors (0.4–72 years) by exploring mitotic and non-mitotic pathways, using telomere length (TL) and age-dependent methylation changes in certain CpG loci (DNAmAge). Heart non-mitotic DNAmAge was strongly younger than that of both blood (− 10 years, p < 0.0001) and chronological age (− 12 years, p < 0.0001). Instead, heart and blood mitotic age (TL) were similar, and there was no difference in DNAmAge and TL between RA and LA. DNAmAge negatively correlated with TL in heart and blood (p ≤ 0.01). Finally, blood and heart TL (p < 0.01) and DNAmAge (p < 0.0001) were correlated. Therefore, blood can be a proxy indicator of heart biological age. While future investigation on post-transplant graft performance in relation to biological aging is still needed, our study could contribute to opening up novel basic and clinical research platforms in the field of organ transplantation. Nature Publishing Group UK 2020-07-01 /pmc/articles/PMC7329913/ /pubmed/32612244 http://dx.doi.org/10.1038/s41598-020-67622-1 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Pavanello, Sofia Campisi, Manuela Fabozzo, Assunta Cibin, Giorgia Tarzia, Vincenzo Toscano, Giuseppe Gerosa, Gino The biological age of the heart is consistently younger than chronological age |
title | The biological age of the heart is consistently younger than chronological age |
title_full | The biological age of the heart is consistently younger than chronological age |
title_fullStr | The biological age of the heart is consistently younger than chronological age |
title_full_unstemmed | The biological age of the heart is consistently younger than chronological age |
title_short | The biological age of the heart is consistently younger than chronological age |
title_sort | biological age of the heart is consistently younger than chronological age |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329913/ https://www.ncbi.nlm.nih.gov/pubmed/32612244 http://dx.doi.org/10.1038/s41598-020-67622-1 |
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