Efficient CRISPR-Cas9-Mediated Gene Ablation in Human Keratinocytes to Recapitulate Genodermatoses: Modeling of Netherton Syndrome

Current efforts to find specific genodermatoses treatments and define precise pathogenesis mechanisms require appropriate surrogate models with human cells. Although transgenic and gene knockout mouse models for several of these disorders exist, they often fail to faithfully replicate the clinical a...

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Detalles Bibliográficos
Autores principales: Gálvez, Victoria, Chacón-Solano, Esteban, Bonafont, Jose, Mencía, Ángeles, Di, Wei-Li, Murillas, Rodolfo, Llames, Sara, Vicente, Asunción, Del Rio, Marcela, Carretero, Marta, Larcher, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329935/
https://www.ncbi.nlm.nih.gov/pubmed/32637457
http://dx.doi.org/10.1016/j.omtm.2020.05.031

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