Mutation in Bmpr1b Leads to Optic Disc Coloboma and Ventral Retinal Gliosis in Mice

PURPOSE: The clinical phenotype of retinal gliosis occurs in different forms; here, we characterize one novel genetic feature, (i.e., signaling via BMP-receptor 1b). METHODS: Mouse mutants were generated within a recessive ENU mutagenesis screen; the underlying mutation was identified by linkage ana...

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Detalles Bibliográficos
Autores principales: Yan, Xiaohe, Atorf, Jenny, Ramos, David, Thiele, Frank, Weber, Susanne, Dalke, Claudia, Sun, Minxuan, Puk, Oliver, Michel, Dian, Fuchs, Helmut, Klaften, Matthias, Przemeck, Gerhard K H., Sabrautzki, Sibylle, Favor, Jack, Ruberte, Jesús, Kremers, Jan, de Angelis, Martin Hrabě, Graw, Jochen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2020
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329948/
https://www.ncbi.nlm.nih.gov/pubmed/32106289
http://dx.doi.org/10.1167/iovs.61.2.44

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