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Optimization of quantitative time-resolved 3D (4D) digital subtraction angiography in a porcine liver model

BACKGROUND: Time-resolved three-dimensional digital subtraction angiography (4D-DSA) can be used to quantify blood velocity. Contrast pulsatility, a major discriminant on 4D-DSA, is yet to be optimized. We investigated the effects of different imaging and injection parameters on sideband ratio (SBR)...

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Autores principales: Meram, Ece, Shaughnessy, Gabe, Longhurst, Colin, Hoffman, Carson, Wagner, Martin, Mistretta, Charles A., Speidel, Michael A., Laeseke, Paul F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329977/
https://www.ncbi.nlm.nih.gov/pubmed/32613472
http://dx.doi.org/10.1186/s41747-020-00164-3
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author Meram, Ece
Shaughnessy, Gabe
Longhurst, Colin
Hoffman, Carson
Wagner, Martin
Mistretta, Charles A.
Speidel, Michael A.
Laeseke, Paul F.
author_facet Meram, Ece
Shaughnessy, Gabe
Longhurst, Colin
Hoffman, Carson
Wagner, Martin
Mistretta, Charles A.
Speidel, Michael A.
Laeseke, Paul F.
author_sort Meram, Ece
collection PubMed
description BACKGROUND: Time-resolved three-dimensional digital subtraction angiography (4D-DSA) can be used to quantify blood velocity. Contrast pulsatility, a major discriminant on 4D-DSA, is yet to be optimized. We investigated the effects of different imaging and injection parameters on sideband ratio (SBR), a measure of contrast pulsatile strength, within the hepatic vasculature of an in vivo porcine model. METHODS: Fifty-nine hepatic 4D-DSA procedures were performed in three female domestic swine (mean weight 54 kg). Contrast injections were performed in the common hepatic artery with different combinations of imaging duration (6 s or 12 s), injection rates (from 1.0 to 2.5 mL/s), contrast concentration (50% or 100%), and catheter size (4 Fr or 5 Fr). Reflux was recorded. SBR and vessel cross-sectional areas were calculated in 289 arterial segments. Multiple linear mixed-effects models were estimated to determine the effects of parameters on SBR and cross-sectional vessel area. RESULTS: Twelve-second acquisitions yielded a SBR higher than 6 s (p < 0.001). No significant differences in SBR were seen between different catheter sizes (p = 0.063) or contrast concentration (p = 0.907). For higher injection rates (2.5 mL/s), SBR was lower (p = 0.007) and cross-sectional area was higher (p < 0.001). Reflux of contrast does not significantly affect SBR (p = 0.087). CONCLUSIONS: The strength of contrast pulsatility used for flow quantitation with 4D-DSA can be increased by adjusting injection rates and using longer acquisition times. Reduction of contrast concentration to 50% is feasible and reflux of contrast does not significantly hinder contrast pulsatility.
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spelling pubmed-73299772020-07-07 Optimization of quantitative time-resolved 3D (4D) digital subtraction angiography in a porcine liver model Meram, Ece Shaughnessy, Gabe Longhurst, Colin Hoffman, Carson Wagner, Martin Mistretta, Charles A. Speidel, Michael A. Laeseke, Paul F. Eur Radiol Exp Original Article BACKGROUND: Time-resolved three-dimensional digital subtraction angiography (4D-DSA) can be used to quantify blood velocity. Contrast pulsatility, a major discriminant on 4D-DSA, is yet to be optimized. We investigated the effects of different imaging and injection parameters on sideband ratio (SBR), a measure of contrast pulsatile strength, within the hepatic vasculature of an in vivo porcine model. METHODS: Fifty-nine hepatic 4D-DSA procedures were performed in three female domestic swine (mean weight 54 kg). Contrast injections were performed in the common hepatic artery with different combinations of imaging duration (6 s or 12 s), injection rates (from 1.0 to 2.5 mL/s), contrast concentration (50% or 100%), and catheter size (4 Fr or 5 Fr). Reflux was recorded. SBR and vessel cross-sectional areas were calculated in 289 arterial segments. Multiple linear mixed-effects models were estimated to determine the effects of parameters on SBR and cross-sectional vessel area. RESULTS: Twelve-second acquisitions yielded a SBR higher than 6 s (p < 0.001). No significant differences in SBR were seen between different catheter sizes (p = 0.063) or contrast concentration (p = 0.907). For higher injection rates (2.5 mL/s), SBR was lower (p = 0.007) and cross-sectional area was higher (p < 0.001). Reflux of contrast does not significantly affect SBR (p = 0.087). CONCLUSIONS: The strength of contrast pulsatility used for flow quantitation with 4D-DSA can be increased by adjusting injection rates and using longer acquisition times. Reduction of contrast concentration to 50% is feasible and reflux of contrast does not significantly hinder contrast pulsatility. Springer International Publishing 2020-07-02 /pmc/articles/PMC7329977/ /pubmed/32613472 http://dx.doi.org/10.1186/s41747-020-00164-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Article
Meram, Ece
Shaughnessy, Gabe
Longhurst, Colin
Hoffman, Carson
Wagner, Martin
Mistretta, Charles A.
Speidel, Michael A.
Laeseke, Paul F.
Optimization of quantitative time-resolved 3D (4D) digital subtraction angiography in a porcine liver model
title Optimization of quantitative time-resolved 3D (4D) digital subtraction angiography in a porcine liver model
title_full Optimization of quantitative time-resolved 3D (4D) digital subtraction angiography in a porcine liver model
title_fullStr Optimization of quantitative time-resolved 3D (4D) digital subtraction angiography in a porcine liver model
title_full_unstemmed Optimization of quantitative time-resolved 3D (4D) digital subtraction angiography in a porcine liver model
title_short Optimization of quantitative time-resolved 3D (4D) digital subtraction angiography in a porcine liver model
title_sort optimization of quantitative time-resolved 3d (4d) digital subtraction angiography in a porcine liver model
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329977/
https://www.ncbi.nlm.nih.gov/pubmed/32613472
http://dx.doi.org/10.1186/s41747-020-00164-3
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