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Stereotactic Radiotherapy for the Management of Refractory Ventricular Tachycardia: Promise and Future Directions
Ventricular tachycardia (VT) caused by myocardial scaring bears a significant risk of mortality and morbidity. Antiarrhythmic drug therapy (AAD) and catheter ablation remain the cornerstone of VT management, but both treatments have limited efficacy and potential adverse effects. Stereotactic body r...
| Autores principales: | , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329991/ https://www.ncbi.nlm.nih.gov/pubmed/32671101 http://dx.doi.org/10.3389/fcvm.2020.00108 |
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| author | Jumeau, Raphael Ozsahin, Mahmut Schwitter, Juerg Elicin, Olgun Reichlin, Tobias Roten, Laurent Andratschke, Nicolaus Mayinger, Michael Saguner, Ardan M. Steffel, Jan Blanck, Oliver Vozenin, Marie-Catherine Moeckli, Raphael Zeverino, Michele Vallet, Véronique Herrera-Siklody, Claudia Pascale, Patrizio Bourhis, Jean Pruvot, Etienne |
| author_facet | Jumeau, Raphael Ozsahin, Mahmut Schwitter, Juerg Elicin, Olgun Reichlin, Tobias Roten, Laurent Andratschke, Nicolaus Mayinger, Michael Saguner, Ardan M. Steffel, Jan Blanck, Oliver Vozenin, Marie-Catherine Moeckli, Raphael Zeverino, Michele Vallet, Véronique Herrera-Siklody, Claudia Pascale, Patrizio Bourhis, Jean Pruvot, Etienne |
| author_sort | Jumeau, Raphael |
| collection | PubMed |
| description | Ventricular tachycardia (VT) caused by myocardial scaring bears a significant risk of mortality and morbidity. Antiarrhythmic drug therapy (AAD) and catheter ablation remain the cornerstone of VT management, but both treatments have limited efficacy and potential adverse effects. Stereotactic body radiotherapy (SBRT) is routinely used in oncology to treat non-invasively solid tumors with high precision and efficacy. Recently, this technology has been evaluated for the treatment of VT. This review presents the basic underlying principles, proof of concept, and main results of trials and case series that used SBRT for the treatment of VT refractory to AAD and catheter ablation. |
| format | Online Article Text |
| id | pubmed-7329991 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Frontiers Media S.A. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-73299912020-07-14 Stereotactic Radiotherapy for the Management of Refractory Ventricular Tachycardia: Promise and Future Directions Jumeau, Raphael Ozsahin, Mahmut Schwitter, Juerg Elicin, Olgun Reichlin, Tobias Roten, Laurent Andratschke, Nicolaus Mayinger, Michael Saguner, Ardan M. Steffel, Jan Blanck, Oliver Vozenin, Marie-Catherine Moeckli, Raphael Zeverino, Michele Vallet, Véronique Herrera-Siklody, Claudia Pascale, Patrizio Bourhis, Jean Pruvot, Etienne Front Cardiovasc Med Cardiovascular Medicine Ventricular tachycardia (VT) caused by myocardial scaring bears a significant risk of mortality and morbidity. Antiarrhythmic drug therapy (AAD) and catheter ablation remain the cornerstone of VT management, but both treatments have limited efficacy and potential adverse effects. Stereotactic body radiotherapy (SBRT) is routinely used in oncology to treat non-invasively solid tumors with high precision and efficacy. Recently, this technology has been evaluated for the treatment of VT. This review presents the basic underlying principles, proof of concept, and main results of trials and case series that used SBRT for the treatment of VT refractory to AAD and catheter ablation. Frontiers Media S.A. 2020-06-25 /pmc/articles/PMC7329991/ /pubmed/32671101 http://dx.doi.org/10.3389/fcvm.2020.00108 Text en Copyright © 2020 Jumeau, Ozsahin, Schwitter, Elicin, Reichlin, Roten, Andratschke, Mayinger, Saguner, Steffel, Blanck, Vozenin, Moeckli, Zeverino, Vallet, Herrera-Siklody, Pascale, Bourhis and Pruvot. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| spellingShingle | Cardiovascular Medicine Jumeau, Raphael Ozsahin, Mahmut Schwitter, Juerg Elicin, Olgun Reichlin, Tobias Roten, Laurent Andratschke, Nicolaus Mayinger, Michael Saguner, Ardan M. Steffel, Jan Blanck, Oliver Vozenin, Marie-Catherine Moeckli, Raphael Zeverino, Michele Vallet, Véronique Herrera-Siklody, Claudia Pascale, Patrizio Bourhis, Jean Pruvot, Etienne Stereotactic Radiotherapy for the Management of Refractory Ventricular Tachycardia: Promise and Future Directions |
| title | Stereotactic Radiotherapy for the Management of Refractory Ventricular Tachycardia: Promise and Future Directions |
| title_full | Stereotactic Radiotherapy for the Management of Refractory Ventricular Tachycardia: Promise and Future Directions |
| title_fullStr | Stereotactic Radiotherapy for the Management of Refractory Ventricular Tachycardia: Promise and Future Directions |
| title_full_unstemmed | Stereotactic Radiotherapy for the Management of Refractory Ventricular Tachycardia: Promise and Future Directions |
| title_short | Stereotactic Radiotherapy for the Management of Refractory Ventricular Tachycardia: Promise and Future Directions |
| title_sort | stereotactic radiotherapy for the management of refractory ventricular tachycardia: promise and future directions |
| topic | Cardiovascular Medicine |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329991/ https://www.ncbi.nlm.nih.gov/pubmed/32671101 http://dx.doi.org/10.3389/fcvm.2020.00108 |
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