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In vivo Assessment of Supra-Cervical Fetal Membrane by MRI 3D CISS: A Preliminary Study

In approximately 8% of term births and 33% of pre-term births, the fetal membrane (FM) ruptures before delivery. In vitro studies of FMs after delivery have suggested the series of events leading to rupture, but no in vivo studies have confirmed this model. In this study, we used a three-dimensional...

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Autores principales: Qi, Wenxu, Zhao, Peinan, Wang, Wei, Sun, Zhexian, Ma, Xiao, Wang, Hui, Wu, Wenjie, Wen, Zichao, Kisrieva-Ware, Zulfia, Woodard, Pamela K., Wang, Qing, McKinstry, Robert C., Wang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330018/
https://www.ncbi.nlm.nih.gov/pubmed/32670086
http://dx.doi.org/10.3389/fphys.2020.00639
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author Qi, Wenxu
Zhao, Peinan
Wang, Wei
Sun, Zhexian
Ma, Xiao
Wang, Hui
Wu, Wenjie
Wen, Zichao
Kisrieva-Ware, Zulfia
Woodard, Pamela K.
Wang, Qing
McKinstry, Robert C.
Wang, Yong
author_facet Qi, Wenxu
Zhao, Peinan
Wang, Wei
Sun, Zhexian
Ma, Xiao
Wang, Hui
Wu, Wenjie
Wen, Zichao
Kisrieva-Ware, Zulfia
Woodard, Pamela K.
Wang, Qing
McKinstry, Robert C.
Wang, Yong
author_sort Qi, Wenxu
collection PubMed
description In approximately 8% of term births and 33% of pre-term births, the fetal membrane (FM) ruptures before delivery. In vitro studies of FMs after delivery have suggested the series of events leading to rupture, but no in vivo studies have confirmed this model. In this study, we used a three-dimensional constructive interference in steady state (3D-CISS) sequence to examine the FM at the cervical internal os zone during pregnancy; 18 pregnant women with one to three longitudinal MRI scans were included in this study. In 14 women, the FM appeared normal and completely intact. In four women, we noted several FM abnormalities including cervical funneling, chorioamniotic separation, and chorion rupture. Our data support the in vitro model that the FM ruptures according to a sequence starting with the stretch of chorion and amnion, then the separation of amnion from chorion, next the rupture of chorion, and finally the rupture of amnion ruptures. These findings hold great promise to help to develop an in vivo magnetic resonance imaging marker that improves examination of the FMs.
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spelling pubmed-73300182020-07-14 In vivo Assessment of Supra-Cervical Fetal Membrane by MRI 3D CISS: A Preliminary Study Qi, Wenxu Zhao, Peinan Wang, Wei Sun, Zhexian Ma, Xiao Wang, Hui Wu, Wenjie Wen, Zichao Kisrieva-Ware, Zulfia Woodard, Pamela K. Wang, Qing McKinstry, Robert C. Wang, Yong Front Physiol Physiology In approximately 8% of term births and 33% of pre-term births, the fetal membrane (FM) ruptures before delivery. In vitro studies of FMs after delivery have suggested the series of events leading to rupture, but no in vivo studies have confirmed this model. In this study, we used a three-dimensional constructive interference in steady state (3D-CISS) sequence to examine the FM at the cervical internal os zone during pregnancy; 18 pregnant women with one to three longitudinal MRI scans were included in this study. In 14 women, the FM appeared normal and completely intact. In four women, we noted several FM abnormalities including cervical funneling, chorioamniotic separation, and chorion rupture. Our data support the in vitro model that the FM ruptures according to a sequence starting with the stretch of chorion and amnion, then the separation of amnion from chorion, next the rupture of chorion, and finally the rupture of amnion ruptures. These findings hold great promise to help to develop an in vivo magnetic resonance imaging marker that improves examination of the FMs. Frontiers Media S.A. 2020-06-25 /pmc/articles/PMC7330018/ /pubmed/32670086 http://dx.doi.org/10.3389/fphys.2020.00639 Text en Copyright © 2020 Qi, Zhao, Wang, Sun, Ma, Wang, Wu, Wen, Kisrieva-Ware, Woodard, Wang, McKinstry and Wang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Qi, Wenxu
Zhao, Peinan
Wang, Wei
Sun, Zhexian
Ma, Xiao
Wang, Hui
Wu, Wenjie
Wen, Zichao
Kisrieva-Ware, Zulfia
Woodard, Pamela K.
Wang, Qing
McKinstry, Robert C.
Wang, Yong
In vivo Assessment of Supra-Cervical Fetal Membrane by MRI 3D CISS: A Preliminary Study
title In vivo Assessment of Supra-Cervical Fetal Membrane by MRI 3D CISS: A Preliminary Study
title_full In vivo Assessment of Supra-Cervical Fetal Membrane by MRI 3D CISS: A Preliminary Study
title_fullStr In vivo Assessment of Supra-Cervical Fetal Membrane by MRI 3D CISS: A Preliminary Study
title_full_unstemmed In vivo Assessment of Supra-Cervical Fetal Membrane by MRI 3D CISS: A Preliminary Study
title_short In vivo Assessment of Supra-Cervical Fetal Membrane by MRI 3D CISS: A Preliminary Study
title_sort in vivo assessment of supra-cervical fetal membrane by mri 3d ciss: a preliminary study
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330018/
https://www.ncbi.nlm.nih.gov/pubmed/32670086
http://dx.doi.org/10.3389/fphys.2020.00639
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