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The effect of hypothalamic peptides, neurohormone C and proline-rich peptide-1on the Ca(2+)-handling system in heartin pathophysiological conditions

Atthe Institute of Biochemistry named after H. Buniatyan we discovered and studied hypothalamic peptides with coronary dilatory and antioxidant activities:neurohormone C (NC) and proline-rich peptide-1 (PRP-1). Both NC and PRP-1 exhibit cardioprotective effects, in part by restoring the calcium affi...

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Autor principal: Guevorkian, Artashes G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330072/
https://www.ncbi.nlm.nih.gov/pubmed/32637717
http://dx.doi.org/10.1016/j.heliyon.2020.e04360
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author Guevorkian, Artashes G.
author_facet Guevorkian, Artashes G.
author_sort Guevorkian, Artashes G.
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description Atthe Institute of Biochemistry named after H. Buniatyan we discovered and studied hypothalamic peptides with coronary dilatory and antioxidant activities:neurohormone C (NC) and proline-rich peptide-1 (PRP-1). Both NC and PRP-1 exhibit cardioprotective effects, in part by restoring the calcium affinity for calcium-binding membrane proteins in cardiomyocytes. This affinity is diminished in the sarcoplasmic reticulum and mitochondriawith myocardial damage, heart failure, pancreatic necrosis and crush syndrome caused by isoproterenol. The peptides can also destroy the four detected toxic peptides and myocardial depressant factor, and protect against ischemia-reperfusion injury. Further studies of these peptides may be promising for the treatment of patients at high risk of cardiovascular disease, regardless of pathology.
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spelling pubmed-73300722020-07-06 The effect of hypothalamic peptides, neurohormone C and proline-rich peptide-1on the Ca(2+)-handling system in heartin pathophysiological conditions Guevorkian, Artashes G. Heliyon Article Atthe Institute of Biochemistry named after H. Buniatyan we discovered and studied hypothalamic peptides with coronary dilatory and antioxidant activities:neurohormone C (NC) and proline-rich peptide-1 (PRP-1). Both NC and PRP-1 exhibit cardioprotective effects, in part by restoring the calcium affinity for calcium-binding membrane proteins in cardiomyocytes. This affinity is diminished in the sarcoplasmic reticulum and mitochondriawith myocardial damage, heart failure, pancreatic necrosis and crush syndrome caused by isoproterenol. The peptides can also destroy the four detected toxic peptides and myocardial depressant factor, and protect against ischemia-reperfusion injury. Further studies of these peptides may be promising for the treatment of patients at high risk of cardiovascular disease, regardless of pathology. Elsevier 2020-06-29 /pmc/articles/PMC7330072/ /pubmed/32637717 http://dx.doi.org/10.1016/j.heliyon.2020.e04360 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Guevorkian, Artashes G.
The effect of hypothalamic peptides, neurohormone C and proline-rich peptide-1on the Ca(2+)-handling system in heartin pathophysiological conditions
title The effect of hypothalamic peptides, neurohormone C and proline-rich peptide-1on the Ca(2+)-handling system in heartin pathophysiological conditions
title_full The effect of hypothalamic peptides, neurohormone C and proline-rich peptide-1on the Ca(2+)-handling system in heartin pathophysiological conditions
title_fullStr The effect of hypothalamic peptides, neurohormone C and proline-rich peptide-1on the Ca(2+)-handling system in heartin pathophysiological conditions
title_full_unstemmed The effect of hypothalamic peptides, neurohormone C and proline-rich peptide-1on the Ca(2+)-handling system in heartin pathophysiological conditions
title_short The effect of hypothalamic peptides, neurohormone C and proline-rich peptide-1on the Ca(2+)-handling system in heartin pathophysiological conditions
title_sort effect of hypothalamic peptides, neurohormone c and proline-rich peptide-1on the ca(2+)-handling system in heartin pathophysiological conditions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330072/
https://www.ncbi.nlm.nih.gov/pubmed/32637717
http://dx.doi.org/10.1016/j.heliyon.2020.e04360
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