A rare case of acute myeloid leukemia with t(12;19)(q13;q13)

Acute myeloid leukemia (AML) is characterized by chromosomal abnormalities affecting both prognosis and course of treatment. While most AML patients have well described chromosomal aberrations, around 10% present with rare chromosomal abnormalities. We herein, report a rare balanced translocation t(...

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Autores principales: Chebly, Alain, Haddad, Fady Gh, Bassil, Josiane, Yammine, Tony, Korban, Rima, Semaan, Warde, El Karak, Fady, Kourie, Hampig Raphael, Farra, Chantal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330145/
https://www.ncbi.nlm.nih.gov/pubmed/32637310
http://dx.doi.org/10.1016/j.lrr.2020.100216
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author Chebly, Alain
Haddad, Fady Gh
Bassil, Josiane
Yammine, Tony
Korban, Rima
Semaan, Warde
El Karak, Fady
Kourie, Hampig Raphael
Farra, Chantal
author_facet Chebly, Alain
Haddad, Fady Gh
Bassil, Josiane
Yammine, Tony
Korban, Rima
Semaan, Warde
El Karak, Fady
Kourie, Hampig Raphael
Farra, Chantal
author_sort Chebly, Alain
collection PubMed
description Acute myeloid leukemia (AML) is characterized by chromosomal abnormalities affecting both prognosis and course of treatment. While most AML patients have well described chromosomal aberrations, around 10% present with rare chromosomal abnormalities. We herein, report a rare balanced translocation t(12;19)(q13;q13) in a 66-year old M5-AML patient identified by Conventional cytogenetic analysis and confirmed by SNP array. We suggest that t(12;19) as a sole chromosomal abnormality could be associated with a poor prognosis. Further studies are needed to understand the molecular basis of this translocation in AML.
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spelling pubmed-73301452020-07-06 A rare case of acute myeloid leukemia with t(12;19)(q13;q13) Chebly, Alain Haddad, Fady Gh Bassil, Josiane Yammine, Tony Korban, Rima Semaan, Warde El Karak, Fady Kourie, Hampig Raphael Farra, Chantal Leuk Res Rep Article Acute myeloid leukemia (AML) is characterized by chromosomal abnormalities affecting both prognosis and course of treatment. While most AML patients have well described chromosomal aberrations, around 10% present with rare chromosomal abnormalities. We herein, report a rare balanced translocation t(12;19)(q13;q13) in a 66-year old M5-AML patient identified by Conventional cytogenetic analysis and confirmed by SNP array. We suggest that t(12;19) as a sole chromosomal abnormality could be associated with a poor prognosis. Further studies are needed to understand the molecular basis of this translocation in AML. Elsevier 2020-06-27 /pmc/articles/PMC7330145/ /pubmed/32637310 http://dx.doi.org/10.1016/j.lrr.2020.100216 Text en © 2020 Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Chebly, Alain
Haddad, Fady Gh
Bassil, Josiane
Yammine, Tony
Korban, Rima
Semaan, Warde
El Karak, Fady
Kourie, Hampig Raphael
Farra, Chantal
A rare case of acute myeloid leukemia with t(12;19)(q13;q13)
title A rare case of acute myeloid leukemia with t(12;19)(q13;q13)
title_full A rare case of acute myeloid leukemia with t(12;19)(q13;q13)
title_fullStr A rare case of acute myeloid leukemia with t(12;19)(q13;q13)
title_full_unstemmed A rare case of acute myeloid leukemia with t(12;19)(q13;q13)
title_short A rare case of acute myeloid leukemia with t(12;19)(q13;q13)
title_sort rare case of acute myeloid leukemia with t(12;19)(q13;q13)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330145/
https://www.ncbi.nlm.nih.gov/pubmed/32637310
http://dx.doi.org/10.1016/j.lrr.2020.100216
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