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Impact of concurrent genomic alterations in epidermal growth factor receptor (EGFR)-mutated lung cancer

Comprehensive characterization of the genomic landscape of epidermal growth factor receptor (EGFR)-mutated lung cancers have identified patterns of secondary mutations beyond the primary oncogenic EGFR mutation. These include concurrent pathogenic alterations affecting p53 (60–65%), RTKs (5–10%), PI...

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Detalles Bibliográficos
Autores principales:	Gini, Beatrice, Thomas, Nicholas, Blakely, Collin M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2020
Materias:	Review Article on Mechanisms of Resistance to EGFR-targeted Therapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330397/ https://www.ncbi.nlm.nih.gov/pubmed/32642201 http://dx.doi.org/10.21037/jtd.2020.03.78

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