Characterization of Astrocytic Response after Experiencing Cavitation In Vitro (Global Challenges 7/2020)

Low‐pressure regions inside the skull can cause vapor contents in the cerebral spinal fluid to expand and collapse in traumatic brain injury (TBI). Using cell‐laden microfibers, Nicole N. Hashemi and co‐workers visually analyzed the longitudinal morphological response that astrocytes express to surr...

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Autores principales: Wrede, Alex H., McNamara, Marilyn C., Baldwin, Rodger, Luo, Jie, Montazami, Reza, Kanthasamy, Anumantha, Hashemi, Nicole N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Cover Picture
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330504/
http://dx.doi.org/10.1002/gch2.202070071
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author Wrede, Alex H.
McNamara, Marilyn C.
Baldwin, Rodger
Luo, Jie
Montazami, Reza
Kanthasamy, Anumantha
Hashemi, Nicole N.
author_facet Wrede, Alex H.
McNamara, Marilyn C.
Baldwin, Rodger
Luo, Jie
Montazami, Reza
Kanthasamy, Anumantha
Hashemi, Nicole N.
author_sort Wrede, Alex H.
collection PubMed
description Low‐pressure regions inside the skull can cause vapor contents in the cerebral spinal fluid to expand and collapse in traumatic brain injury (TBI). Using cell‐laden microfibers, Nicole N. Hashemi and co‐workers visually analyzed the longitudinal morphological response that astrocytes express to surrounding cavitation in vitro. Genetic analytics were conducted post‐cavitation to show drastic upregulation in TBI‐related genes. Astrocytes are known to be neurotoxic after cranial insult, and this study, described in article 1900014, confirms the adverse effects that cavitation has on the astrocytic phenotype. [Image: see text]
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spelling pubmed-73305042020-07-07 Characterization of Astrocytic Response after Experiencing Cavitation In Vitro (Global Challenges 7/2020) Wrede, Alex H. McNamara, Marilyn C. Baldwin, Rodger Luo, Jie Montazami, Reza Kanthasamy, Anumantha Hashemi, Nicole N. Glob Chall Cover Picture Low‐pressure regions inside the skull can cause vapor contents in the cerebral spinal fluid to expand and collapse in traumatic brain injury (TBI). Using cell‐laden microfibers, Nicole N. Hashemi and co‐workers visually analyzed the longitudinal morphological response that astrocytes express to surrounding cavitation in vitro. Genetic analytics were conducted post‐cavitation to show drastic upregulation in TBI‐related genes. Astrocytes are known to be neurotoxic after cranial insult, and this study, described in article 1900014, confirms the adverse effects that cavitation has on the astrocytic phenotype. [Image: see text] John Wiley and Sons Inc. 2020-07-02 /pmc/articles/PMC7330504/ http://dx.doi.org/10.1002/gch2.202070071 Text en © 2020 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Cover Picture
Wrede, Alex H.
McNamara, Marilyn C.
Baldwin, Rodger
Luo, Jie
Montazami, Reza
Kanthasamy, Anumantha
Hashemi, Nicole N.
Characterization of Astrocytic Response after Experiencing Cavitation In Vitro (Global Challenges 7/2020)
title Characterization of Astrocytic Response after Experiencing Cavitation In Vitro (Global Challenges 7/2020)
title_full Characterization of Astrocytic Response after Experiencing Cavitation In Vitro (Global Challenges 7/2020)
title_fullStr Characterization of Astrocytic Response after Experiencing Cavitation In Vitro (Global Challenges 7/2020)
title_full_unstemmed Characterization of Astrocytic Response after Experiencing Cavitation In Vitro (Global Challenges 7/2020)
title_short Characterization of Astrocytic Response after Experiencing Cavitation In Vitro (Global Challenges 7/2020)
title_sort characterization of astrocytic response after experiencing cavitation in vitro (global challenges 7/2020)
topic Cover Picture
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330504/
http://dx.doi.org/10.1002/gch2.202070071
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