Kinetic Analysis of the Early Signaling Steps of the Human Chemokine Receptor CXCR4

G protein–coupled receptors (GPCRs) are biologic switches that transduce extracellular stimuli into intracellular responses in the cell. Temporally resolving GPCR transduction pathways is key to understanding how cell signaling occurs. Here, we investigate the kinetics and dynamics of the activation...

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Detalles Bibliográficos
Autores principales: Perpiñá-Viciano, Cristina, Işbilir, Ali, Zarca, Aurélien, Caspar, Birgit, Kilpatrick, Laura E., Hill, Stephen J., Smit, Martine J., Lohse, Martin J., Hoffmann, Carsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330677/
https://www.ncbi.nlm.nih.gov/pubmed/32474443
http://dx.doi.org/10.1124/mol.119.118448

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