Dual inhibition of PFKFB3 and VEGF normalizes tumor vasculature, reduces lactate production, and improves chemotherapy in glioblastoma: insights from protein expression profiling and MRI

Rationale: Tumor vascular normalization (TVN) is emerging to enhance the efficacy of anticancer treatment in many cancers including glioblastoma (GBM). However, a common and severe challenge being currently faced is the transient TVN effect, hampering the sustained administration of anticancer thera...

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Detalles Bibliográficos
Autores principales: Zhang, Junfeng, Xue, Wei, Xu, Kai, Yi, Liang, Guo, Yu, Xie, Tian, Tong, Haipeng, Zhou, Bo, Wang, Shunan, Li, Qing, Liu, Heng, Chen, Xiao, Fang, Jingqin, Zhang, Weiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330843/
https://www.ncbi.nlm.nih.gov/pubmed/32641990
http://dx.doi.org/10.7150/thno.44427

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