Establishment of reference range of CD4 T-lymphocyte in healthy Nepalese adults

OBJECTIVE: CD4 T lymphocytes are the most widely used cellular markers to assess the course of HIV infection, clinical staging and, monitoring the effect of antiretroviral therapy. The regional reference range for Eastern, Central and Western development region of Nepal had already been established...

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Autores principales: Mishra, Shravan Kumar, Shrestha, Lilee, Pandit, Roshan, Khadka, Sundar, Shrestha, Bimal, Dhital, Subhash, Sharma, Saroj, Sharma, Mukunda, Mahato, Raj Kumar, Shakya, Geeta, Das Manandhar, Krishna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
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Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330941/
https://www.ncbi.nlm.nih.gov/pubmed/32616011
http://dx.doi.org/10.1186/s13104-020-05156-5
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author Mishra, Shravan Kumar
Shrestha, Lilee
Pandit, Roshan
Khadka, Sundar
Shrestha, Bimal
Dhital, Subhash
Sharma, Saroj
Sharma, Mukunda
Mahato, Raj Kumar
Shakya, Geeta
Das Manandhar, Krishna
author_facet Mishra, Shravan Kumar
Shrestha, Lilee
Pandit, Roshan
Khadka, Sundar
Shrestha, Bimal
Dhital, Subhash
Sharma, Saroj
Sharma, Mukunda
Mahato, Raj Kumar
Shakya, Geeta
Das Manandhar, Krishna
author_sort Mishra, Shravan Kumar
collection PubMed
description OBJECTIVE: CD4 T lymphocytes are the most widely used cellular markers to assess the course of HIV infection, clinical staging and, monitoring the effect of antiretroviral therapy. The regional reference range for Eastern, Central and Western development region of Nepal had already been established whereas the same was still lacking in Mid-western and Far-western development region. The objective of this study was to establish reference range of CD4 T lymphocyte in the remaining two development regions and finally the national reference range using data from previous study. RESULTS: The average values (mean ± SD) of CD4 and CD3 T cell in present study was (819 ± 294) cells/μl and (1546 ± 532) cells/μl, respectively. The absolute CD4 T cell (914 ± 303) and CD3 T cell (1671 ± 560) count in female were significantly higher than those from male, CD4 (757 ± 270) and CD3 (1465 ± 499) (p value-0.000). National reference value of CD4 was determined to be (798 ± 335) cells/μl for healthy Nepalese adults.
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spelling pubmed-73309412020-07-02 Establishment of reference range of CD4 T-lymphocyte in healthy Nepalese adults Mishra, Shravan Kumar Shrestha, Lilee Pandit, Roshan Khadka, Sundar Shrestha, Bimal Dhital, Subhash Sharma, Saroj Sharma, Mukunda Mahato, Raj Kumar Shakya, Geeta Das Manandhar, Krishna BMC Res Notes Research Note OBJECTIVE: CD4 T lymphocytes are the most widely used cellular markers to assess the course of HIV infection, clinical staging and, monitoring the effect of antiretroviral therapy. The regional reference range for Eastern, Central and Western development region of Nepal had already been established whereas the same was still lacking in Mid-western and Far-western development region. The objective of this study was to establish reference range of CD4 T lymphocyte in the remaining two development regions and finally the national reference range using data from previous study. RESULTS: The average values (mean ± SD) of CD4 and CD3 T cell in present study was (819 ± 294) cells/μl and (1546 ± 532) cells/μl, respectively. The absolute CD4 T cell (914 ± 303) and CD3 T cell (1671 ± 560) count in female were significantly higher than those from male, CD4 (757 ± 270) and CD3 (1465 ± 499) (p value-0.000). National reference value of CD4 was determined to be (798 ± 335) cells/μl for healthy Nepalese adults. BioMed Central 2020-07-02 /pmc/articles/PMC7330941/ /pubmed/32616011 http://dx.doi.org/10.1186/s13104-020-05156-5 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Note
Mishra, Shravan Kumar
Shrestha, Lilee
Pandit, Roshan
Khadka, Sundar
Shrestha, Bimal
Dhital, Subhash
Sharma, Saroj
Sharma, Mukunda
Mahato, Raj Kumar
Shakya, Geeta
Das Manandhar, Krishna
Establishment of reference range of CD4 T-lymphocyte in healthy Nepalese adults
title Establishment of reference range of CD4 T-lymphocyte in healthy Nepalese adults
title_full Establishment of reference range of CD4 T-lymphocyte in healthy Nepalese adults
title_fullStr Establishment of reference range of CD4 T-lymphocyte in healthy Nepalese adults
title_full_unstemmed Establishment of reference range of CD4 T-lymphocyte in healthy Nepalese adults
title_short Establishment of reference range of CD4 T-lymphocyte in healthy Nepalese adults
title_sort establishment of reference range of cd4 t-lymphocyte in healthy nepalese adults
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330941/
https://www.ncbi.nlm.nih.gov/pubmed/32616011
http://dx.doi.org/10.1186/s13104-020-05156-5
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