SARS-CoV-2 does not replicate in embryonated hen’s eggs or in MDCK cell lines

The advent of COVID-19, has posed a risk that human respiratory samples containing human influenza viruses may also contain SARS-CoV-2. This potential risk may lead to SARS-CoV-2 contaminating conventional influenza vaccine production platforms as respiratory samples are used to directly inoculate e...

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Autores principales: Barr, Ian G, Rynehart, Cleve, Whitney, Paul, Druce, Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2020
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331139/
https://www.ncbi.nlm.nih.gov/pubmed/32613937
http://dx.doi.org/10.2807/1560-7917.ES.2020.25.25.2001122
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author Barr, Ian G
Rynehart, Cleve
Whitney, Paul
Druce, Julian
author_facet Barr, Ian G
Rynehart, Cleve
Whitney, Paul
Druce, Julian
author_sort Barr, Ian G
collection PubMed
description The advent of COVID-19, has posed a risk that human respiratory samples containing human influenza viruses may also contain SARS-CoV-2. This potential risk may lead to SARS-CoV-2 contaminating conventional influenza vaccine production platforms as respiratory samples are used to directly inoculate embryonated hen’s eggs and continuous cell lines that are used to isolate and produce influenza vaccines. We investigated the ability of these substrates to propagate SARS-CoV-2 and found that neither could support SARS-CoV-2 replication.
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spelling pubmed-73311392020-07-06 SARS-CoV-2 does not replicate in embryonated hen’s eggs or in MDCK cell lines Barr, Ian G Rynehart, Cleve Whitney, Paul Druce, Julian Euro Surveill Rapid Communication The advent of COVID-19, has posed a risk that human respiratory samples containing human influenza viruses may also contain SARS-CoV-2. This potential risk may lead to SARS-CoV-2 contaminating conventional influenza vaccine production platforms as respiratory samples are used to directly inoculate embryonated hen’s eggs and continuous cell lines that are used to isolate and produce influenza vaccines. We investigated the ability of these substrates to propagate SARS-CoV-2 and found that neither could support SARS-CoV-2 replication. European Centre for Disease Prevention and Control (ECDC) 2020-06-25 /pmc/articles/PMC7331139/ /pubmed/32613937 http://dx.doi.org/10.2807/1560-7917.ES.2020.25.25.2001122 Text en This article is copyright of the authors or their affiliated institutions, 2020. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Rapid Communication
Barr, Ian G
Rynehart, Cleve
Whitney, Paul
Druce, Julian
SARS-CoV-2 does not replicate in embryonated hen’s eggs or in MDCK cell lines
title SARS-CoV-2 does not replicate in embryonated hen’s eggs or in MDCK cell lines
title_full SARS-CoV-2 does not replicate in embryonated hen’s eggs or in MDCK cell lines
title_fullStr SARS-CoV-2 does not replicate in embryonated hen’s eggs or in MDCK cell lines
title_full_unstemmed SARS-CoV-2 does not replicate in embryonated hen’s eggs or in MDCK cell lines
title_short SARS-CoV-2 does not replicate in embryonated hen’s eggs or in MDCK cell lines
title_sort sars-cov-2 does not replicate in embryonated hen’s eggs or in mdck cell lines
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331139/
https://www.ncbi.nlm.nih.gov/pubmed/32613937
http://dx.doi.org/10.2807/1560-7917.ES.2020.25.25.2001122
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