Rapid spread of OXA-244-producing Escherichia coli ST38 in Germany: insights from an integrated molecular surveillance approach; 2017 to January 2020

Annually, increasing numbers of OXA-244-producing Escherichia coli in 13 German federal states prompted us to initiate an outbreak investigation. Whole genome sequencing revealed that among 148 isolates analysed, most belonged to sequence type 38 with 62 isolates forming a genetically distinct clust...

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Autores principales: Kremer, Katrin, Kramer, Rolf, Neumann, Bernd, Haller, Sebastian, Pfennigwerth, Niels, Werner, Guido, Gatermann, Sören, Schroten, Horst, Eckmanns, Tim, Hans, Jörg B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2020
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331143/
https://www.ncbi.nlm.nih.gov/pubmed/32613940
http://dx.doi.org/10.2807/1560-7917.ES.2020.25.25.2000923
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author Kremer, Katrin
Kramer, Rolf
Neumann, Bernd
Haller, Sebastian
Pfennigwerth, Niels
Werner, Guido
Gatermann, Sören
Schroten, Horst
Eckmanns, Tim
Hans, Jörg B
author_facet Kremer, Katrin
Kramer, Rolf
Neumann, Bernd
Haller, Sebastian
Pfennigwerth, Niels
Werner, Guido
Gatermann, Sören
Schroten, Horst
Eckmanns, Tim
Hans, Jörg B
author_sort Kremer, Katrin
collection PubMed
description Annually, increasing numbers of OXA-244-producing Escherichia coli in 13 German federal states prompted us to initiate an outbreak investigation. Whole genome sequencing revealed that among 148 isolates analysed, most belonged to sequence type 38 with 62 isolates forming a genetically distinct cluster. Although no epidemiological link could be identified between cases, ongoing investigations suggest non-healthcare associated transmission. A screening-PCR was developed facilitating early detection of ST38 cluster isolates to identify the source and transmission route.
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spelling pubmed-73311432020-07-06 Rapid spread of OXA-244-producing Escherichia coli ST38 in Germany: insights from an integrated molecular surveillance approach; 2017 to January 2020 Kremer, Katrin Kramer, Rolf Neumann, Bernd Haller, Sebastian Pfennigwerth, Niels Werner, Guido Gatermann, Sören Schroten, Horst Eckmanns, Tim Hans, Jörg B Euro Surveill Rapid Communication Annually, increasing numbers of OXA-244-producing Escherichia coli in 13 German federal states prompted us to initiate an outbreak investigation. Whole genome sequencing revealed that among 148 isolates analysed, most belonged to sequence type 38 with 62 isolates forming a genetically distinct cluster. Although no epidemiological link could be identified between cases, ongoing investigations suggest non-healthcare associated transmission. A screening-PCR was developed facilitating early detection of ST38 cluster isolates to identify the source and transmission route. European Centre for Disease Prevention and Control (ECDC) 2020-06-25 /pmc/articles/PMC7331143/ /pubmed/32613940 http://dx.doi.org/10.2807/1560-7917.ES.2020.25.25.2000923 Text en This article is copyright of the authors or their affiliated institutions, 2020. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Rapid Communication
Kremer, Katrin
Kramer, Rolf
Neumann, Bernd
Haller, Sebastian
Pfennigwerth, Niels
Werner, Guido
Gatermann, Sören
Schroten, Horst
Eckmanns, Tim
Hans, Jörg B
Rapid spread of OXA-244-producing Escherichia coli ST38 in Germany: insights from an integrated molecular surveillance approach; 2017 to January 2020
title Rapid spread of OXA-244-producing Escherichia coli ST38 in Germany: insights from an integrated molecular surveillance approach; 2017 to January 2020
title_full Rapid spread of OXA-244-producing Escherichia coli ST38 in Germany: insights from an integrated molecular surveillance approach; 2017 to January 2020
title_fullStr Rapid spread of OXA-244-producing Escherichia coli ST38 in Germany: insights from an integrated molecular surveillance approach; 2017 to January 2020
title_full_unstemmed Rapid spread of OXA-244-producing Escherichia coli ST38 in Germany: insights from an integrated molecular surveillance approach; 2017 to January 2020
title_short Rapid spread of OXA-244-producing Escherichia coli ST38 in Germany: insights from an integrated molecular surveillance approach; 2017 to January 2020
title_sort rapid spread of oxa-244-producing escherichia coli st38 in germany: insights from an integrated molecular surveillance approach; 2017 to january 2020
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331143/
https://www.ncbi.nlm.nih.gov/pubmed/32613940
http://dx.doi.org/10.2807/1560-7917.ES.2020.25.25.2000923
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