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How Does the Mono-Triazole Derivative Modulate Aβ(42) Aggregation and Disrupt a Protofibril Structure: Insights from Molecular Dynamics Simulations

[Image: see text] Clinical studies have identified that abnormal self-assembly of amyloid-β (Aβ) peptide into toxic fibrillar aggregates is associated with the pathology of Alzheimer’s disease (AD). The most acceptable therapeutic approach to stop the progression of AD is to inhibit the formation of...

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Detalles Bibliográficos
Autores principales:	Kaur, Amandeep, Kaur, Anupamjeet, Goyal, Deepti, Goyal, Bhupesh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331201/ https://www.ncbi.nlm.nih.gov/pubmed/32637837 http://dx.doi.org/10.1021/acsomega.0c01825

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