Synthesis of Heteroannulated Indolopyrazines through Domino N–H Palladium-Catalyzed/Metal-Free Oxidative C–H Bond Activation

[Image: see text] A convenient approach to [1,2,5]oxadiazolo[3′,4′:5,6]pyrazino[2,3-b]indoles and their heteroannulated analogues bearing various aryl substituents in the backbone has been developed. This synthetic protocol is based on Pd-catalyzed Buchwald–Hartwig and subsequent annulation by intra...

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Autores principales: Kvashnin, Yuriy A., Verbitskiy, Egor V., Zhilina, Ekaterina F., Rusinov, Gennady L., Chupakhin, Oleg N., Charushin, Valery N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331205/
https://www.ncbi.nlm.nih.gov/pubmed/32637843
http://dx.doi.org/10.1021/acsomega.0c01945
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author Kvashnin, Yuriy A.
Verbitskiy, Egor V.
Zhilina, Ekaterina F.
Rusinov, Gennady L.
Chupakhin, Oleg N.
Charushin, Valery N.
author_facet Kvashnin, Yuriy A.
Verbitskiy, Egor V.
Zhilina, Ekaterina F.
Rusinov, Gennady L.
Chupakhin, Oleg N.
Charushin, Valery N.
author_sort Kvashnin, Yuriy A.
collection PubMed
description [Image: see text] A convenient approach to [1,2,5]oxadiazolo[3′,4′:5,6]pyrazino[2,3-b]indoles and their heteroannulated analogues bearing various aryl substituents in the backbone has been developed. This synthetic protocol is based on Pd-catalyzed Buchwald–Hartwig and subsequent annulation by intramolecular oxidative cyclodehydrogenation. The photophysical properties for new polycycles have been measured.
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spelling pubmed-73312052020-07-06 Synthesis of Heteroannulated Indolopyrazines through Domino N–H Palladium-Catalyzed/Metal-Free Oxidative C–H Bond Activation Kvashnin, Yuriy A. Verbitskiy, Egor V. Zhilina, Ekaterina F. Rusinov, Gennady L. Chupakhin, Oleg N. Charushin, Valery N. ACS Omega [Image: see text] A convenient approach to [1,2,5]oxadiazolo[3′,4′:5,6]pyrazino[2,3-b]indoles and their heteroannulated analogues bearing various aryl substituents in the backbone has been developed. This synthetic protocol is based on Pd-catalyzed Buchwald–Hartwig and subsequent annulation by intramolecular oxidative cyclodehydrogenation. The photophysical properties for new polycycles have been measured. American Chemical Society 2020-06-18 /pmc/articles/PMC7331205/ /pubmed/32637843 http://dx.doi.org/10.1021/acsomega.0c01945 Text en Copyright © 2020 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Kvashnin, Yuriy A.
Verbitskiy, Egor V.
Zhilina, Ekaterina F.
Rusinov, Gennady L.
Chupakhin, Oleg N.
Charushin, Valery N.
Synthesis of Heteroannulated Indolopyrazines through Domino N–H Palladium-Catalyzed/Metal-Free Oxidative C–H Bond Activation
title Synthesis of Heteroannulated Indolopyrazines through Domino N–H Palladium-Catalyzed/Metal-Free Oxidative C–H Bond Activation
title_full Synthesis of Heteroannulated Indolopyrazines through Domino N–H Palladium-Catalyzed/Metal-Free Oxidative C–H Bond Activation
title_fullStr Synthesis of Heteroannulated Indolopyrazines through Domino N–H Palladium-Catalyzed/Metal-Free Oxidative C–H Bond Activation
title_full_unstemmed Synthesis of Heteroannulated Indolopyrazines through Domino N–H Palladium-Catalyzed/Metal-Free Oxidative C–H Bond Activation
title_short Synthesis of Heteroannulated Indolopyrazines through Domino N–H Palladium-Catalyzed/Metal-Free Oxidative C–H Bond Activation
title_sort synthesis of heteroannulated indolopyrazines through domino n–h palladium-catalyzed/metal-free oxidative c–h bond activation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331205/
https://www.ncbi.nlm.nih.gov/pubmed/32637843
http://dx.doi.org/10.1021/acsomega.0c01945
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