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Synthesis of 2,3-Disubstituted 4-Ethoxycarbonyl-β-carbolin-1-ones: Application to the Synthesis of SL651498 and Its Analogue

[Image: see text] Synthesis of 2,3-disubstituted 4-ethoxycarbonyl-β-carbolin-1-ones is developed using palladium-catalyzed intramolecular amination of 3-amino-4-(2-bromophenyl)-2-pyridones prepared by the conjugate addition reaction of diethyl 2-aminomalonate to alkynyl imines. The method was applie...

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Detalles Bibliográficos
Autores principales:	Miura, Ryoya, Goto, Shinsuke, Hashimoto, Takahide, Hachiya, Iwao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331213/ https://www.ncbi.nlm.nih.gov/pubmed/32637839 http://dx.doi.org/10.1021/acsomega.0c01854

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