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Neuroinvasive potential of a primary respiratory pathogen SARS- CoV2: Summarizing the evidences
BACKROUND AND AIMS: After the emergence of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in the last two decades, the world is facing its new challenge in SARS-CoV-2 pandemic with unfathomable global responses. The characteristic...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Diabetes India. Published by Elsevier Ltd.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331527/ https://www.ncbi.nlm.nih.gov/pubmed/32640417 http://dx.doi.org/10.1016/j.dsx.2020.06.062 |
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author | Lahiri, Durjoy Mondal, Ritwick Deb, Shramana Bandyopadhyay, Deebya Shome, Gourav Sarkar, Sukanya Biswas, Subhas C. |
author_facet | Lahiri, Durjoy Mondal, Ritwick Deb, Shramana Bandyopadhyay, Deebya Shome, Gourav Sarkar, Sukanya Biswas, Subhas C. |
author_sort | Lahiri, Durjoy |
collection | PubMed |
description | BACKROUND AND AIMS: After the emergence of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in the last two decades, the world is facing its new challenge in SARS-CoV-2 pandemic with unfathomable global responses. The characteristic clinical symptoms for Coronavirus (COVID-19) affected patients are high fever, dry-cough, dyspnoea, lethal pneumonia whereas some patients also show additional neurological signs such as headache, nausea, vomiting etc. The accumulative evidences suggest that SARS-CoV-2 is not only confined within the respiratory tract but may also invade the central nervous system (CNS) and peripheral nervous system (PNS) inducing some fatal neurological diseases. Here, we analyze the phylogenetic perspective of SARS-CoV-2 with other strains of β-Coronaviridae from a standpoint of neurological spectrum disorders. METHODOLOGY: A Pubmed/Medline, NIH Lit Covid, Cochrane library and some open data bases (BioRxiv, MedRxiv,preprint.org and others) search were carried out by using keywords relevant to our topic of discussion. The extracted literatures are scrutinized by the authors. RESULTS: 58 literatures including original articles, case reports and case series were selected by the authors to analyze the differential distribution of neurological impairments in COVID-19 positive patients along with angiotensin-converting enzyme-2 (ACE2) expression dynamics in neuronal and non-neuronal tissue in CNS and PNS with neuroinvasive potential of SARS-CoV2. CONCLUSION: We discuss the need for modulations in clinical approach from a neurological point of view, as a measure towards reducing disease transmission, morbidity and mortality in SARS-CoV2 positive patients. |
format | Online Article Text |
id | pubmed-7331527 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Diabetes India. Published by Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73315272020-07-06 Neuroinvasive potential of a primary respiratory pathogen SARS- CoV2: Summarizing the evidences Lahiri, Durjoy Mondal, Ritwick Deb, Shramana Bandyopadhyay, Deebya Shome, Gourav Sarkar, Sukanya Biswas, Subhas C. Diabetes Metab Syndr Article BACKROUND AND AIMS: After the emergence of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in the last two decades, the world is facing its new challenge in SARS-CoV-2 pandemic with unfathomable global responses. The characteristic clinical symptoms for Coronavirus (COVID-19) affected patients are high fever, dry-cough, dyspnoea, lethal pneumonia whereas some patients also show additional neurological signs such as headache, nausea, vomiting etc. The accumulative evidences suggest that SARS-CoV-2 is not only confined within the respiratory tract but may also invade the central nervous system (CNS) and peripheral nervous system (PNS) inducing some fatal neurological diseases. Here, we analyze the phylogenetic perspective of SARS-CoV-2 with other strains of β-Coronaviridae from a standpoint of neurological spectrum disorders. METHODOLOGY: A Pubmed/Medline, NIH Lit Covid, Cochrane library and some open data bases (BioRxiv, MedRxiv,preprint.org and others) search were carried out by using keywords relevant to our topic of discussion. The extracted literatures are scrutinized by the authors. RESULTS: 58 literatures including original articles, case reports and case series were selected by the authors to analyze the differential distribution of neurological impairments in COVID-19 positive patients along with angiotensin-converting enzyme-2 (ACE2) expression dynamics in neuronal and non-neuronal tissue in CNS and PNS with neuroinvasive potential of SARS-CoV2. CONCLUSION: We discuss the need for modulations in clinical approach from a neurological point of view, as a measure towards reducing disease transmission, morbidity and mortality in SARS-CoV2 positive patients. Diabetes India. Published by Elsevier Ltd. 2020 2020-07-02 /pmc/articles/PMC7331527/ /pubmed/32640417 http://dx.doi.org/10.1016/j.dsx.2020.06.062 Text en © 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Lahiri, Durjoy Mondal, Ritwick Deb, Shramana Bandyopadhyay, Deebya Shome, Gourav Sarkar, Sukanya Biswas, Subhas C. Neuroinvasive potential of a primary respiratory pathogen SARS- CoV2: Summarizing the evidences |
title | Neuroinvasive potential of a primary respiratory pathogen SARS- CoV2: Summarizing the evidences |
title_full | Neuroinvasive potential of a primary respiratory pathogen SARS- CoV2: Summarizing the evidences |
title_fullStr | Neuroinvasive potential of a primary respiratory pathogen SARS- CoV2: Summarizing the evidences |
title_full_unstemmed | Neuroinvasive potential of a primary respiratory pathogen SARS- CoV2: Summarizing the evidences |
title_short | Neuroinvasive potential of a primary respiratory pathogen SARS- CoV2: Summarizing the evidences |
title_sort | neuroinvasive potential of a primary respiratory pathogen sars- cov2: summarizing the evidences |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331527/ https://www.ncbi.nlm.nih.gov/pubmed/32640417 http://dx.doi.org/10.1016/j.dsx.2020.06.062 |
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