Cargando…

Abrogation of Marek’s disease virus replication using CRISPR/Cas9

Marek’s disease virus (MDV) is a highly cell-associated alphaherpesvirus that causes deadly lymphomas in chickens. While vaccination protects against clinical symptoms, MDV field strains can still circulate in vaccinated flocks and continuously evolve towards greater virulence. MDV vaccines do not p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hagag, Ibrahim T., Wight, Darren J., Bartsch, Denise, Sid, Hicham, Jordan, Ingo, Bertzbach, Luca D., Schusser, Benjamin, Kaufer, Benedikt B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331644/ https://www.ncbi.nlm.nih.gov/pubmed/32616820 http://dx.doi.org/10.1038/s41598-020-67951-1

Ejemplares similares

Acquiring Resistance Against a Retroviral Infection via CRISPR/Cas9 Targeted Genome Editing in a Commercial Chicken Line
por: Hellmich, Romina, et al.
Publicado: (2020)

Characterization of a Novel Viral Interleukin 8 (vIL-8) Splice Variant Encoded by Marek’s Disease Virus
por: You, Yu, et al.
Publicado: (2021)

The Role of Marek’s Disease Virus UL12 and UL29 in DNA Recombination and the Virus Lifecycle
por: Previdelli, Renato L., et al.
Publicado: (2019)

Visualization of Marek’s Disease Virus Genomes in Living Cells during Lytic Replication and Latency
por: Vychodil, Tereza, et al.
Publicado: (2022)

A Special Issue on Marek’s Disease Virus—The Editors’ View
por: Kaufer, Benedikt B., et al.
Publicado: (2023)

Latest Insights into Marek’s Disease Virus Pathogenesis and Tumorigenesis
por: Bertzbach, Luca D., et al.
Publicado: (2020)

Excision of Integrated Human Herpesvirus 6A Genomes Using CRISPR/Cas9 Technology
por: Aimola, Giulia, et al.
Publicado: (2023)

Telomeres and Telomerase: Role in Marek’s Disease Virus Pathogenesis, Integration and Tumorigenesis
por: Kheimar, Ahmed, et al.
Publicado: (2017)

Marek’s Disease Virus Infection of Natural Killer Cells
por: Bertzbach, Luca D., et al.
Publicado: (2019)

IFNα and IFNγ Impede Marek’s Disease Progression
por: Bertzbach, Luca D., et al.
Publicado: (2019)

In vitro infection of primary chicken lymphocytes with Marek’s disease virus
por: Bertzbach, Luca D., et al.
Publicado: (2023)

Marek’s Disease Virus Virulence Genes Encode Circular RNAs
por: Chasseur, Alexis S., et al.
Publicado: (2022)

A Cell Culture System to Investigate Marek’s Disease Virus Integration into Host Chromosomes
por: You, Yu, et al.
Publicado: (2021)

Cas9-expressing chickens and pigs as resources for genome editing in livestock
por: Rieblinger, Beate, et al.
Publicado: (2021)

Replication of Marek's Disease Virus Is Dependent on Synthesis of De Novo Fatty Acid and Prostaglandin E(2)
por: Boodhoo, Nitish, et al.
Publicado: (2019)

Marek’s disease virus prolongs survival of primary chicken B-cells by inducing a senescence-like phenotype
por: Trapp-Fragnet, Laëtitia, et al.
Publicado: (2021)

A Genetically Engineered Commercial Chicken Line Is Resistant to Highly Pathogenic Avian Leukosis Virus Subgroup J
por: Kheimar, Ahmed, et al.
Publicado: (2021)

The Transcriptional Landscape of Marek’s Disease Virus in Primary Chicken B Cells Reveals Novel Splice Variants and Genes
por: Bertzbach, Luca D., et al.
Publicado: (2019)

Imaging Mass Spectrometry and Proteome Analysis of Marek’s Disease Virus-Induced Tumors
por: Pauker, V. I., et al.
Publicado: (2019)

Prevention of Avian Retrovirus Infection in Chickens Using CRISPR-Cas9 Delivered by Marek’s Disease Virus
por: Li, Kai, et al.
Publicado: (2020)

Identification of the Receptor and Cellular Ortholog of the Marek's Disease Virus (MDV) CXC Chemokine
por: Haertle, Sonja, et al.
Publicado: (2017)

Applications of Gene Editing in Chickens: A New Era Is on the Horizon
por: Sid, Hicham, et al.
Publicado: (2018)

The Diverse Major Histocompatibility Complex Haplotypes of a Common Commercial Chicken Line and Their Effect on Marek’s Disease Virus Pathogenesis and Tumorigenesis
por: Bertzbach, Luca D., et al.
Publicado: (2022)

The dominantly expressed class II molecule from a resistant MHC haplotype presents only a few Marek’s disease virus peptides by using an unprecedented binding motif
por: Halabi, Samer, et al.
Publicado: (2021)

Association of Marek’s Disease induced immunosuppression with activation of a novel regulatory T cells in chickens
por: Gurung, Angila, et al.
Publicado: (2017)

Targeted Editing of the pp38 Gene in Marek’s Disease Virus-Transformed Cell Lines Using CRISPR/Cas9 System
por: Zhang, Yaoyao, et al.
Publicado: (2019)

The ND10 Complex Represses Lytic Human Herpesvirus 6A Replication and Promotes Silencing of the Viral Genome
por: Sanyal, Anirban, et al.
Publicado: (2018)

Efficient Mutagenesis of Marek’s Disease Virus-Encoded microRNAs Using a CRISPR/Cas9-Based Gene Editing System
por: Luo, Jun, et al.
Publicado: (2020)

Genetic interference exerted by Salmonella-delivered CRISPR/Cas9 significantly reduces the pathological burden caused by Marek’s disease virus in chickens
por: Senevirathne, Amal, et al.
Publicado: (2021)

Marek’s Disease Virus Modulates T Cell Proliferation via Activation of Cyclooxygenase 2-Dependent Prostaglandin E2
por: Kamble, Nitin, et al.
Publicado: (2021)

V5 and GFP Tagging of Viral Gene pp38 of Marek’s Disease Vaccine Strain CVI988 Using CRISPR/Cas9 Editing
por: Li, Weicheng, et al.
Publicado: (2022)

Efficient Cross-Screening and Characterization of Monoclonal Antibodies against Marek’s Disease Specific Meq Oncoprotein Using CRISPR/Cas9-Gene-Edited Viruses
por: Teng, Man, et al.
Publicado: (2023)

Abrogation of PRRSV infectivity by CRISPR-Cas13b-mediated viral RNA cleavage in mammalian cells
por: Cui, Jin, et al.
Publicado: (2020)

Abrogation of HLA surface expression using CRISPR/Cas9 genome editing: a step toward universal T cell therapy
por: Lee, Jeewon, et al.
Publicado: (2020)

Glutaminolysis and Glycolysis Are Essential for Optimal Replication of Marek’s Disease Virus
por: Boodhoo, Nitish, et al.
Publicado: (2020)

A Single Amino Acid Switch in the Adenoviral DNA Binding Protein Abrogates Replication Center Formation and Productive Viral Infection
por: Boddin, Jana, et al.
Publicado: (2022)

GenomeCRISPR - a database for high-throughput CRISPR/Cas9 screens
por: Rauscher, Benedikt, et al.
Publicado: (2017)

Herpesvirus Telomerase RNA (vTR) with a Mutated Template Sequence Abrogates Herpesvirus-Induced Lymphomagenesis
por: Kaufer, Benedikt B., et al.
Publicado: (2011)

Impact of Host Telomere Length on HHV-6 Integration
por: Wight, Darren J., et al.
Publicado: (2022)

Effect of Insertion and Deletion in the Meq Protein Encoded by Highly Oncogenic Marek’s Disease Virus on Transactivation Activity and Virulence
por: Sato, Jumpei, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_bjom2lul1o0uq3trsfi7caq66s