Altered iron metabolism in cystic fibrosis macrophages: the impact of CFTR modulators and implications for Pseudomonas aeruginosa survival

Cystic fibrosis (CF) is a genetic disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene, resulting in chronic bacterial lung infections and tissue damage. CF macrophages exhibit reduced bacterial killing and increased inflammatory signaling. Iron is elevated in the CF...

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Detalles Bibliográficos
Autores principales: Hazlett, H. F., Hampton, T. H., Aridgides, D. S., Armstrong, D. A., Dessaint, J. A., Mellinger, D. L., Nymon, A. B., Ashare, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331733/
https://www.ncbi.nlm.nih.gov/pubmed/32616918
http://dx.doi.org/10.1038/s41598-020-67729-5

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