LncRNAs as Potential Therapeutic Targets in Thyroid Cancer

Thyroid cancer (TC) is the most common cancer of endocrine system. TC can be subdivided into 4 different entities, papillary, follicular, medullary and anaplastic thyroid cancer. Among them, anaplastic thyroid cancer has the poorest prognosis. Exploring new therapeutic approach may entail favorable...

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Detalles Bibliográficos
Autores principales: Javed, Zeeshan, Shah, Faiez Ahmed, Rajabi, Sadegh, Raza, Qamar, Iqbal, Zaheer, Ullah, Mukhtar, Ahmad, Touqeer, Salehi, Bahare, Sharifi-Rad, Mehdi, Pezzani, Raffaele, Yaqoob, Farooq, Sadia, Haleema, Iriti, Marcello, Sharifi-Rad, Javad, Cho, William C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332117/
https://www.ncbi.nlm.nih.gov/pubmed/32102500
http://dx.doi.org/10.31557/APJCP.2020.21.2.281
Descripción
Sumario:Thyroid cancer (TC) is the most common cancer of endocrine system. TC can be subdivided into 4 different entities, papillary, follicular, medullary and anaplastic thyroid cancer. Among them, anaplastic thyroid cancer has the poorest prognosis. Exploring new therapeutic approach may entail favorable prediction as well as increasing overall survival rate of patients. Long non-coding RNAs (lncRNAs), have vast implications in different cancer types. Although they are not transcribed into proteins, they can act as a harness in regulating a plethora of biological functions. They have been implicated in a decisive role in gene expression via modulation of both coding and non-coding RNAs. This article discuss the multi-facet role of lncRNA in thyroid cancer biology.

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