Protocol for a multinational risk-stratified randomised controlled trial in paediatric Crohn’s disease: methotrexate versus azathioprine or adalimumab for maintaining remission in patients at low or high risk for aggressive disease course

INTRODUCTION: Immunomodulators such as thiopurines (azathioprine (AZA)/6-mercaptopurine (6MP)), methotrexate (MTX) and biologics such as adalimumab (ADA) are well established for maintenance of remission within paediatric Crohn’s disease (CD). It remains unclear, however, which maintenance medicatio...

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Detalles Bibliográficos
Autores principales: Harris, Rachel E, Aloi, Marina, de Ridder, Lissy, Croft, Nicholas M, Koletzko, Sibylle, Levine, Arie, Turner, Dan, Veereman, Gigi, Neyt, Mattias, Bigot, Laetitia, Ruemmele, Frank M, Russell, Richard K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Gastroenterology and Hepatology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332179/
https://www.ncbi.nlm.nih.gov/pubmed/32611737
http://dx.doi.org/10.1136/bmjopen-2019-034892

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