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The Risk of Diabetes on Clinical Outcomes in Patients with Coronavirus Disease 2019: A Retrospective Cohort Study

BACKGROUND: To determine the role of diabetes mellitus (DM) in the coronavirus disease 2019 (COVID-19), we explored the clinical characteristics of patients with DM and compared risk factors such as age, glycemic control, and medications to those without DM. METHODS: This was a retrospective cohort...

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Autores principales: Chung, Seung Min, Lee, Yin Young, Ha, Eunyeong, Yoon, Ji Sung, Won, Kyu Chang, Lee, Hyoung Woo, Hur, Jian, Hong, Kyung Soo, Jang, Jong Geol, Jin, Hyun Jung, Choi, Eun Young, Shin, Kyeong-Cheol, Chung, Jin Hong, Lee, Kwan Ho, Ahn, June Hong, Moon, Jun Sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Diabetes Association 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332325/
https://www.ncbi.nlm.nih.gov/pubmed/32602272
http://dx.doi.org/10.4093/dmj.2020.0105
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author Chung, Seung Min
Lee, Yin Young
Ha, Eunyeong
Yoon, Ji Sung
Won, Kyu Chang
Lee, Hyoung Woo
Hur, Jian
Hong, Kyung Soo
Jang, Jong Geol
Jin, Hyun Jung
Choi, Eun Young
Shin, Kyeong-Cheol
Chung, Jin Hong
Lee, Kwan Ho
Ahn, June Hong
Moon, Jun Sung
author_facet Chung, Seung Min
Lee, Yin Young
Ha, Eunyeong
Yoon, Ji Sung
Won, Kyu Chang
Lee, Hyoung Woo
Hur, Jian
Hong, Kyung Soo
Jang, Jong Geol
Jin, Hyun Jung
Choi, Eun Young
Shin, Kyeong-Cheol
Chung, Jin Hong
Lee, Kwan Ho
Ahn, June Hong
Moon, Jun Sung
author_sort Chung, Seung Min
collection PubMed
description BACKGROUND: To determine the role of diabetes mellitus (DM) in the coronavirus disease 2019 (COVID-19), we explored the clinical characteristics of patients with DM and compared risk factors such as age, glycemic control, and medications to those without DM. METHODS: This was a retrospective cohort study of 117 confirmed patients with COVID-19 which conducted at a tertiary hospital in Daegu, South Korea. The primary outcome was defined as the severe and critical outcome (SCO), of which the composite outcomes of acute respiratory distress syndrome, septic shock, intensive care unit care, and 28-day mortality. We analyzed what clinical features and glycemic control-related factors affect the prognosis of COVID-19 in the DM group. RESULTS: After exclusion, 110 participants were finally included. DM patients (n=29) was older, and showed higher blood pressure compared to non-DM patients. DM group showed higher levels of inflammation-related biomarkers and severity score, and highly progressed to SCO. After adjustment with other risk factors, DM increased the risk of SCO (odds ratio [OR], 10.771; P<0.001). Among the DM patients, SCO was more prevalent in elderly patients of ≥70 years old and age was an independent risk factor for SCO in patients with DM (OR, 1.175; P=0.014), while glycemic control was not. The use of medication did not affect the SCO, but the renin-angiotensin system inhibitors showed protective effects against acute cardiac injury (OR, 0.048; P=0.045). CONCLUSION: The COVID-19 patients with DM had higher severity and resulted in SCO. Intensive and aggressive monitoring of COVID-19 clinical outcomes in DM group, especially in elderly patients is warranted.
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spelling pubmed-73323252020-07-15 The Risk of Diabetes on Clinical Outcomes in Patients with Coronavirus Disease 2019: A Retrospective Cohort Study Chung, Seung Min Lee, Yin Young Ha, Eunyeong Yoon, Ji Sung Won, Kyu Chang Lee, Hyoung Woo Hur, Jian Hong, Kyung Soo Jang, Jong Geol Jin, Hyun Jung Choi, Eun Young Shin, Kyeong-Cheol Chung, Jin Hong Lee, Kwan Ho Ahn, June Hong Moon, Jun Sung Diabetes Metab J Original Article BACKGROUND: To determine the role of diabetes mellitus (DM) in the coronavirus disease 2019 (COVID-19), we explored the clinical characteristics of patients with DM and compared risk factors such as age, glycemic control, and medications to those without DM. METHODS: This was a retrospective cohort study of 117 confirmed patients with COVID-19 which conducted at a tertiary hospital in Daegu, South Korea. The primary outcome was defined as the severe and critical outcome (SCO), of which the composite outcomes of acute respiratory distress syndrome, septic shock, intensive care unit care, and 28-day mortality. We analyzed what clinical features and glycemic control-related factors affect the prognosis of COVID-19 in the DM group. RESULTS: After exclusion, 110 participants were finally included. DM patients (n=29) was older, and showed higher blood pressure compared to non-DM patients. DM group showed higher levels of inflammation-related biomarkers and severity score, and highly progressed to SCO. After adjustment with other risk factors, DM increased the risk of SCO (odds ratio [OR], 10.771; P<0.001). Among the DM patients, SCO was more prevalent in elderly patients of ≥70 years old and age was an independent risk factor for SCO in patients with DM (OR, 1.175; P=0.014), while glycemic control was not. The use of medication did not affect the SCO, but the renin-angiotensin system inhibitors showed protective effects against acute cardiac injury (OR, 0.048; P=0.045). CONCLUSION: The COVID-19 patients with DM had higher severity and resulted in SCO. Intensive and aggressive monitoring of COVID-19 clinical outcomes in DM group, especially in elderly patients is warranted. Korean Diabetes Association 2020-06 2020-05-21 /pmc/articles/PMC7332325/ /pubmed/32602272 http://dx.doi.org/10.4093/dmj.2020.0105 Text en Copyright © 2020 Korean Diabetes Association http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Chung, Seung Min
Lee, Yin Young
Ha, Eunyeong
Yoon, Ji Sung
Won, Kyu Chang
Lee, Hyoung Woo
Hur, Jian
Hong, Kyung Soo
Jang, Jong Geol
Jin, Hyun Jung
Choi, Eun Young
Shin, Kyeong-Cheol
Chung, Jin Hong
Lee, Kwan Ho
Ahn, June Hong
Moon, Jun Sung
The Risk of Diabetes on Clinical Outcomes in Patients with Coronavirus Disease 2019: A Retrospective Cohort Study
title The Risk of Diabetes on Clinical Outcomes in Patients with Coronavirus Disease 2019: A Retrospective Cohort Study
title_full The Risk of Diabetes on Clinical Outcomes in Patients with Coronavirus Disease 2019: A Retrospective Cohort Study
title_fullStr The Risk of Diabetes on Clinical Outcomes in Patients with Coronavirus Disease 2019: A Retrospective Cohort Study
title_full_unstemmed The Risk of Diabetes on Clinical Outcomes in Patients with Coronavirus Disease 2019: A Retrospective Cohort Study
title_short The Risk of Diabetes on Clinical Outcomes in Patients with Coronavirus Disease 2019: A Retrospective Cohort Study
title_sort risk of diabetes on clinical outcomes in patients with coronavirus disease 2019: a retrospective cohort study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332325/
https://www.ncbi.nlm.nih.gov/pubmed/32602272
http://dx.doi.org/10.4093/dmj.2020.0105
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