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The Risk of Diabetes on Clinical Outcomes in Patients with Coronavirus Disease 2019: A Retrospective Cohort Study
BACKGROUND: To determine the role of diabetes mellitus (DM) in the coronavirus disease 2019 (COVID-19), we explored the clinical characteristics of patients with DM and compared risk factors such as age, glycemic control, and medications to those without DM. METHODS: This was a retrospective cohort...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Diabetes Association
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332325/ https://www.ncbi.nlm.nih.gov/pubmed/32602272 http://dx.doi.org/10.4093/dmj.2020.0105 |
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author | Chung, Seung Min Lee, Yin Young Ha, Eunyeong Yoon, Ji Sung Won, Kyu Chang Lee, Hyoung Woo Hur, Jian Hong, Kyung Soo Jang, Jong Geol Jin, Hyun Jung Choi, Eun Young Shin, Kyeong-Cheol Chung, Jin Hong Lee, Kwan Ho Ahn, June Hong Moon, Jun Sung |
author_facet | Chung, Seung Min Lee, Yin Young Ha, Eunyeong Yoon, Ji Sung Won, Kyu Chang Lee, Hyoung Woo Hur, Jian Hong, Kyung Soo Jang, Jong Geol Jin, Hyun Jung Choi, Eun Young Shin, Kyeong-Cheol Chung, Jin Hong Lee, Kwan Ho Ahn, June Hong Moon, Jun Sung |
author_sort | Chung, Seung Min |
collection | PubMed |
description | BACKGROUND: To determine the role of diabetes mellitus (DM) in the coronavirus disease 2019 (COVID-19), we explored the clinical characteristics of patients with DM and compared risk factors such as age, glycemic control, and medications to those without DM. METHODS: This was a retrospective cohort study of 117 confirmed patients with COVID-19 which conducted at a tertiary hospital in Daegu, South Korea. The primary outcome was defined as the severe and critical outcome (SCO), of which the composite outcomes of acute respiratory distress syndrome, septic shock, intensive care unit care, and 28-day mortality. We analyzed what clinical features and glycemic control-related factors affect the prognosis of COVID-19 in the DM group. RESULTS: After exclusion, 110 participants were finally included. DM patients (n=29) was older, and showed higher blood pressure compared to non-DM patients. DM group showed higher levels of inflammation-related biomarkers and severity score, and highly progressed to SCO. After adjustment with other risk factors, DM increased the risk of SCO (odds ratio [OR], 10.771; P<0.001). Among the DM patients, SCO was more prevalent in elderly patients of ≥70 years old and age was an independent risk factor for SCO in patients with DM (OR, 1.175; P=0.014), while glycemic control was not. The use of medication did not affect the SCO, but the renin-angiotensin system inhibitors showed protective effects against acute cardiac injury (OR, 0.048; P=0.045). CONCLUSION: The COVID-19 patients with DM had higher severity and resulted in SCO. Intensive and aggressive monitoring of COVID-19 clinical outcomes in DM group, especially in elderly patients is warranted. |
format | Online Article Text |
id | pubmed-7332325 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Korean Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-73323252020-07-15 The Risk of Diabetes on Clinical Outcomes in Patients with Coronavirus Disease 2019: A Retrospective Cohort Study Chung, Seung Min Lee, Yin Young Ha, Eunyeong Yoon, Ji Sung Won, Kyu Chang Lee, Hyoung Woo Hur, Jian Hong, Kyung Soo Jang, Jong Geol Jin, Hyun Jung Choi, Eun Young Shin, Kyeong-Cheol Chung, Jin Hong Lee, Kwan Ho Ahn, June Hong Moon, Jun Sung Diabetes Metab J Original Article BACKGROUND: To determine the role of diabetes mellitus (DM) in the coronavirus disease 2019 (COVID-19), we explored the clinical characteristics of patients with DM and compared risk factors such as age, glycemic control, and medications to those without DM. METHODS: This was a retrospective cohort study of 117 confirmed patients with COVID-19 which conducted at a tertiary hospital in Daegu, South Korea. The primary outcome was defined as the severe and critical outcome (SCO), of which the composite outcomes of acute respiratory distress syndrome, septic shock, intensive care unit care, and 28-day mortality. We analyzed what clinical features and glycemic control-related factors affect the prognosis of COVID-19 in the DM group. RESULTS: After exclusion, 110 participants were finally included. DM patients (n=29) was older, and showed higher blood pressure compared to non-DM patients. DM group showed higher levels of inflammation-related biomarkers and severity score, and highly progressed to SCO. After adjustment with other risk factors, DM increased the risk of SCO (odds ratio [OR], 10.771; P<0.001). Among the DM patients, SCO was more prevalent in elderly patients of ≥70 years old and age was an independent risk factor for SCO in patients with DM (OR, 1.175; P=0.014), while glycemic control was not. The use of medication did not affect the SCO, but the renin-angiotensin system inhibitors showed protective effects against acute cardiac injury (OR, 0.048; P=0.045). CONCLUSION: The COVID-19 patients with DM had higher severity and resulted in SCO. Intensive and aggressive monitoring of COVID-19 clinical outcomes in DM group, especially in elderly patients is warranted. Korean Diabetes Association 2020-06 2020-05-21 /pmc/articles/PMC7332325/ /pubmed/32602272 http://dx.doi.org/10.4093/dmj.2020.0105 Text en Copyright © 2020 Korean Diabetes Association http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Chung, Seung Min Lee, Yin Young Ha, Eunyeong Yoon, Ji Sung Won, Kyu Chang Lee, Hyoung Woo Hur, Jian Hong, Kyung Soo Jang, Jong Geol Jin, Hyun Jung Choi, Eun Young Shin, Kyeong-Cheol Chung, Jin Hong Lee, Kwan Ho Ahn, June Hong Moon, Jun Sung The Risk of Diabetes on Clinical Outcomes in Patients with Coronavirus Disease 2019: A Retrospective Cohort Study |
title | The Risk of Diabetes on Clinical Outcomes in Patients with Coronavirus Disease 2019: A Retrospective Cohort Study |
title_full | The Risk of Diabetes on Clinical Outcomes in Patients with Coronavirus Disease 2019: A Retrospective Cohort Study |
title_fullStr | The Risk of Diabetes on Clinical Outcomes in Patients with Coronavirus Disease 2019: A Retrospective Cohort Study |
title_full_unstemmed | The Risk of Diabetes on Clinical Outcomes in Patients with Coronavirus Disease 2019: A Retrospective Cohort Study |
title_short | The Risk of Diabetes on Clinical Outcomes in Patients with Coronavirus Disease 2019: A Retrospective Cohort Study |
title_sort | risk of diabetes on clinical outcomes in patients with coronavirus disease 2019: a retrospective cohort study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332325/ https://www.ncbi.nlm.nih.gov/pubmed/32602272 http://dx.doi.org/10.4093/dmj.2020.0105 |
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